CAS 1161826-19-2

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-fluoroethyl)-3,4-dihydro-4-oxo-

Description:

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-fluoroethyl)-3,4-dihydro-4-oxo- is a complex organic compound characterized by its unique heterocyclic structure, which includes both imidazole and tetrazine moieties. This compound features a carboxamide functional group, contributing to its potential solubility in polar solvents and its reactivity in various chemical reactions. The presence of a fluoroethyl group enhances its biological activity and may influence its pharmacokinetic properties, making it of interest in medicinal chemistry. The compound's structure suggests potential applications in drug development, particularly in targeting specific biological pathways. Additionally, the presence of multiple nitrogen atoms in the tetrazine ring may impart unique electronic properties, affecting its stability and reactivity. Overall, this compound exemplifies the intricate interplay of structural features that can lead to diverse chemical behaviors and potential applications in various fields, including pharmaceuticals and materials science.

Formula: C₇H₇FN₆O₂

Synonyms:

• Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-fluoroethyl)-3,4-dihydro-4-oxo-

KL-50

CAS: 1161826-19-2

KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.

Formula: C₇H₇FN₆O₂

Color and Shape: Solid

Molecular weight: 226.17

Ref: TM-T200136