CAS 1162-60-3

-4-TIBOLONE

Description:

4-Tibolone, with the CAS number 1162-60-3, is a synthetic steroid that exhibits properties similar to both estrogen and progestin. It is primarily used in hormone replacement therapy, particularly for postmenopausal women, to alleviate symptoms such as hot flashes and to prevent osteoporosis. The compound functions as a selective tissue estrogenic activity regulator (STEAR), meaning it can exert estrogenic effects in certain tissues while acting as an anti-estrogen in others. This selective action helps to minimize some of the risks associated with traditional hormone replacement therapies. 4-Tibolone is characterized by its lipophilic nature, allowing it to be readily absorbed and distributed in the body. Its metabolism produces active metabolites that contribute to its therapeutic effects. While it is effective in managing menopausal symptoms, its use may be associated with certain risks, including potential impacts on breast tissue and cardiovascular health, necessitating careful consideration and monitoring by healthcare providers. Overall, 4-Tibolone represents a significant advancement in hormone therapy, offering a tailored approach to managing menopausal symptoms.

Formula: C₂₁H₂₈O₂

InChI: InChI=1/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,12-13,16-19,23H,5-11H2,2-3H3

InChI key: InChIKey=WAOKMNBZWBGYIK-KIURNNQRSA-N

SMILES: C[C@H]1[C@]2([C@]3([C@@](C)([C@@](C#C)(O)CC3)CC[C@@]2([C@@]4(C(C1)=CC(=O)CC4)[H])[H])[H])[H]

Synonyms:

• (7Alpha)-17-Ethynyl-17-Hydroxy-7-Methylestr-4-En-3-One
• (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one
• 17-Ethynyl-17-Hydroxy-7-Methylestr-4-En-3-One
• 17a-Ethynyl-17-hydroxy-7a-methyl-4-estren-3-one
• 17β-Hydroxy-17α-ethynyl-7α-methylestr-4-en-3-one
• 19-Nor-17α-pregn-4-en-20-yn-3-one, 17-hydroxy-7α-methyl-
• 19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-
• 7a-Methylnorethindrone
• 7α-Methyl-17α-ethynyl-19-nortestosterone
• Isotibolone
• Nsc 142228
• Org-OM 38
• Δ⁴-Tibolone
• Gestrinone Impurity 8
• Org OD 14 4-ene isomer
• -4-TIBOLONE
• 7α-Methyl-17β-hydroxy-17-ethynylestra-4-ene-3-one
• 17α-Ethynyl-17
• -hydroxy-7α-Methyl-4-estren-3-one

δ 4-Tibolone

Controlled Product

CAS: 1162-60-3

Applications A metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
References Clarkson, T., et al.: J. Clin. Endocrinol. Metab., 86, 5396 (2001), Landgren, M., et al.: Maturitas, 50, 222 (2005), Wang, M., et al.: Steroids, 71, 343 (2006), Verheul, H., et al.: Drug Metab. Dispos., 35, 1105 (2007),

Formula: C₂₁H₂₈O₂

Color and Shape: Neat

Molecular weight: 312.45

Ref: TR-T437505

δ4-Tibolone (1mg/ml in Acetonitrile)

Controlled Product

CAS: 1162-60-3

Formula: C₂₁H₂₈O₂

Color and Shape: Single Solution

Molecular weight: 312.45

Ref: TR-KIT7535

∆4-Tibolone-13C,d3

Controlled Product

CAS: 1162-60-3

Applications A labelled metabolite of Tibolone. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
References Clarkson, T., et al.: J. Clin. Endocrinol. Metab., 86, 5396 (2001), Landgren, M., et al.: Maturitas, 50, 222 (2005), Wang, M., et al.: Steroids, 71, 343 (2006), Verheul, H., et al.: Drug Metab. Dispos., 35, 1105 (2007),

Formula: C₂₀₁₃CH₂₅D₃O₂

Color and Shape: Neat

Molecular weight: 316.46

Ref: TR-T437507

δ-4-Tibolone

Controlled Product

CAS: 1162-60-3

Tibolone is a synthetic steroid with progesterone-like activity. It binds to the progesterone receptor, which is primarily located in the uterus and ovaries. Tibolone has been shown to be an effective treatment for postmenopausal osteoporosis and may also have non-hormonal effects on the central nervous system, such as anti-depressant and anti-anxiety effects. Tibolone binds to the progesterone receptor through a stepwise process, binding more strongly than progesterone due to its substitution of a hydroxyl group at C4 for hydrogen. Tibolone has also been shown to be an effective overtraining prevention agent, by reducing the risk of neural injury during exercise. This drug can also be used as an effective treatment against depression, anxiety and overtraining syndrome.

Formula: C₂₁H₂₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 312.45 g/mol

Ref: 3D-FT28267

19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-

CAS: 1162-60-3

Formula: C₂₁H₂₈O₂

Color and Shape: Solid

Molecular weight: 312.4458

Ref: IN-DA000BW0