CAS 116308-55-5

Watanidipine

Description:

Watanidipine is a chemical compound classified as a calcium channel blocker, primarily used in the treatment of hypertension and certain cardiovascular conditions. It functions by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissues, leading to vasodilation and a subsequent decrease in blood pressure. The compound is characterized by its specific molecular structure, which includes a dihydropyridine ring, a common feature among calcium channel blockers. Watanidipine exhibits a relatively high selectivity for vascular tissues over cardiac tissues, which helps minimize potential side effects associated with cardiac depression. Its pharmacokinetic profile includes moderate absorption and a metabolism that may involve hepatic pathways, influencing its bioavailability and duration of action. As with many medications, potential side effects can include dizziness, headache, and peripheral edema. Overall, Watanidipine represents a valuable therapeutic option in managing hypertension, contributing to improved cardiovascular health.

Formula: C₄₁H₄₂N₄O₆

InChI: InChI=1S/C41H42N4O6/c1-28-36(40(46)50-3)38(33-15-10-16-35(27-33)45(48)49)37(29(2)42-28)41(47)51-26-21-30-17-19-34(20-18-30)43-22-24-44(25-23-43)39(31-11-6-4-7-12-31)32-13-8-5-9-14-32/h4-20,27,38-39,42H,21-26H2,1-3H3

InChI key: InChIKey=OTTHUQAYARCXLP-UHFFFAOYSA-N

SMILES: C(OCCC1=CC=C(C=C1)N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)(=O)C=5C(C(C(OC)=O)=C(C)NC5C)C6=CC(N(=O)=O)=CC=C6

Synonyms:

• Watanidipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-[4-(diphenylmethyl)-1-piperazinyl]phenyl]ethyl] 5-methyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-[4-(diphenylmethyl)-1-piperazinyl]phenyl]ethyl methyl ester
• 2-{4-[4-(diphenylmethyl)piperazin-1-yl]phenyl}ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Vatanidipine

Vatanidipine

CAS: 116308-55-5

Vatanidipine

Purity: ≥98%

Molecular weight: 686.8g/mol

Ref: 54-BUP12360

Vatanidipine

CAS: 116308-55-5

Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting

Formula: C₄₁H₄₂N₄O₆

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 686.8

Ref: TM-T24932