CAS 116371-67-6

2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid

Description:

2'-Deoxy-2',2'-difluoro-5'-cytidylic acid, commonly referred to as a modified nucleoside, is a synthetic derivative of cytidine. This compound features two fluorine atoms substituted at the 2' position of the ribose sugar, which enhances its stability and alters its interaction with nucleic acids. The presence of fluorine can influence the compound's biological activity, potentially affecting its role in nucleic acid synthesis and function. As a nucleotide analog, it may be utilized in research related to antiviral therapies or as a tool in molecular biology to study nucleic acid processes. The modification can also impact its solubility, binding affinity, and overall pharmacokinetics. The CAS number 116371-67-6 uniquely identifies this compound in chemical databases, facilitating its study and application in various scientific fields. Overall, 2'-Deoxy-2',2'-difluoro-5'-cytidylic acid exemplifies how structural modifications can lead to significant changes in the properties and functionalities of nucleoside derivatives.

Formula: C₉H₁₂F₂N₃O₇P

InChI: InChI=1/C9H12F2N3O7P/c10-9(11)6(15)4(3-20-22(17,18)19)21-7(9)14-2-1-5(12)13-8(14)16/h1-2,4,6-7,15H,3H2,(H2,12,13,16)(H2,17,18,19)/t4-,6+,7-/m1/s1

Synonyms:

• Gemcitabine Monophosphate

5'-Cytidylic acid, 2'-deoxy-2',2'-difluoro-

CAS: 116371-67-6

Formula: C₉H₁₂F₂N₃O₇P

Purity: 97%

Color and Shape: Solid

Molecular weight: 343.1780

Ref: IN-DA000CBP

Gemcitabine monophosphate formate salt

CAS: 116371-67-6

Formula: C₁₀H₁₄F₂N₃O₉P

Purity: ≥ 90.0%

Color and Shape: White to off-white solid

Molecular weight: 389.20

Ref: 7W-GN1379

((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

CAS: 116371-67-6

((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate

Purity: 97%

Molecular weight: 343.18g/mol

Ref: 54-PC1007830

Gemcitabine Monophosphate

CAS: 116371-67-6

Applications Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.
References Balzarini, J., et al.: Biochem. Pharmacol., 37, 897 (1988), Abbruzzese, J., et al.: Investig. New Drugs, 7, 195 (1989), Balzarini, J., et al.: J. Biol. Chem., 264, 6127 (1989), Chu, C., et al.: Antimicrob. Agents Chemother., 39, 979 (1995)

Formula: C₉H₁₂F₂N₃O₇P

Color and Shape: White To Off-White

Molecular weight: 343.18

Ref: TR-G305005

2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate

CAS: 116371-67-6

2'-Deoxy-2',2'-difluorocytidine 5'-monophosphate (CDFMP) is a potent antitumor agent that has been shown to have a strong anti-angiogenic effect. It inhibits the cancer cell's production of microvessels and interferes with the formation of new blood vessels from pre-existing ones, which can be used to deliver chemotherapy drugs to the tumor. CDFMP is synthesized by reacting 2'-deoxy-2',2'-difluorocytidine with phosphoric acid and then converting it into the monophosphate form using phosphorus oxychloride. This drug is also resistant to platinum-based chemotherapy agents, making it a promising drug for patients who are resistant to other treatments.

Formula: C₉H₁₂F₂N₃O₇P

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 343.18 g/mol

Ref: 3D-NG16551

Gemcitabine Monophosphate-15N3

Controlled Product

CAS: 116371-67-6

Formula: C₉H₁₂F₂₁₅N₃O₇P

Color and Shape: Neat

Molecular weight: 346.158

Ref: TR-G305007

Gemcitabine Monophosphate

CAS: 116371-67-6

Formula: C₉H₁₂F₂N₃O₇P

Molecular weight: 343.18

Ref: ST-EA-CP-G7008

Gemcitabine monophosphate

CAS: 116371-67-6

R306465, a potent HDAC1/8 inhibitor, has broad antitumor effects (IC50: 30-300 nM) on solid and blood cancers.

Formula: C₉H₁₂F₂N₃O₇P

Color and Shape: Solid

Molecular weight: 343.18

Ref: TM-T21329