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CAS 116470-67-8

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2-(Trifluoromethyl)pyrimidine

Description:
2-(Trifluoromethyl)pyrimidine is a heterocyclic organic compound characterized by the presence of a pyrimidine ring substituted with a trifluoromethyl group at the second position. This compound features a six-membered aromatic ring containing two nitrogen atoms at the 1 and 3 positions, which is typical of pyrimidines. The trifluoromethyl group (-CF3) is known for its electron-withdrawing properties, which can significantly influence the reactivity and polarity of the molecule. As a result, 2-(Trifluoromethyl)pyrimidine exhibits unique chemical behavior, making it valuable in various applications, particularly in medicinal chemistry and agrochemicals. The presence of fluorine atoms enhances the compound's lipophilicity and metabolic stability, which can be advantageous in drug design. Additionally, this compound may participate in various chemical reactions, including nucleophilic substitutions and coupling reactions, making it a useful intermediate in the synthesis of more complex molecules. Its physical properties, such as boiling point and solubility, are influenced by the trifluoromethyl group, contributing to its overall utility in chemical research and development.
Formula:C5H3F3N2
InChI:InChI=1S/C5H3F3N2/c6-5(7,8)4-9-2-1-3-10-4/h1-3H
InChI key:InChIKey=BQDJLAWUTBCDHK-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C=1N=CC=CN1
Synonyms:
  • 2-Trifluoromethyl pyrimidine
  • Pyrimidine, 2-(trifluoromethyl)-
  • Pyrimidine, 2-(trifluoromethyl)- (9CI)
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