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CAS 116539-59-4

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Duloxetine

Description:
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) primarily used as an antidepressant and for the treatment of generalized anxiety disorder, fibromyalgia, and neuropathic pain. Its chemical formula is C18H19NOS, and it features a bicyclic structure that includes a phenyl ring and a thiophene moiety. Duloxetine is known for its ability to increase the levels of serotonin and norepinephrine in the synaptic cleft by inhibiting their reuptake, which contributes to its therapeutic effects. The substance is typically administered in capsule form and is well-absorbed in the gastrointestinal tract, with a bioavailability that can be affected by food intake. Duloxetine has a moderate half-life, allowing for once or twice daily dosing. Common side effects may include nausea, dry mouth, and fatigue, while more serious risks involve potential increases in blood pressure and serotonin syndrome. As with any medication, it is essential to use duloxetine under medical supervision to monitor for efficacy and adverse effects.
Formula:C18H19NOS
InChI:InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
InChI key:InChIKey=ZEUITGRIYCTCEM-KRWDZBQOSA-N
SMILES:O([C@@H](CCNC)C1=CC=CS1)C=2C3=C(C=CC2)C=CC=C3
Synonyms:
  • (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine
  • (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
  • (R)-Duloxetine
  • (R)-N-Methyl-Gama-(1-Naphthalenyloxy)-2-Thiophenepropanamine
  • (S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
  • (S)-Duloxetine
  • (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
  • (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine
  • 2-Thiophenepropanamine N-methyl-γ-(1-naphthalenyloxy)-, (γS)-
  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-
  • See more synonyms
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Found 6 products.