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CAS 116539-60-7

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(R)-Duloxetine

Description:
(R)-Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) primarily used in the treatment of major depressive disorder and generalized anxiety disorder. It is characterized by its chiral nature, with the (R)-enantiomer being the active form that exhibits pharmacological effects. The molecular formula of (R)-Duloxetine includes carbon, hydrogen, nitrogen, and oxygen, reflecting its complex structure. It typically appears as a white to off-white crystalline powder and is soluble in organic solvents like methanol and ethanol, but has limited solubility in water. The compound functions by inhibiting the reuptake of serotonin and norepinephrine in the brain, thereby increasing their availability in the synaptic cleft, which contributes to its antidepressant and anxiolytic effects. (R)-Duloxetine is also associated with a range of side effects, including nausea, dry mouth, and fatigue, and it is contraindicated in certain conditions, such as uncontrolled hypertension. Its pharmacokinetics involve extensive metabolism in the liver, primarily through cytochrome P450 enzymes, leading to various metabolites.
Formula:C18H19NOS
InChI:InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m1/s1
InChI key:InChIKey=ZEUITGRIYCTCEM-QGZVFWFLSA-N
SMILES:O([C@H](CCNC)C1=CC=CS1)C=2C3=C(C=CC2)C=CC=C3
Synonyms:
  • (3R)-N-methyl-3-(naphthalen-1-yloxy)-3-thiophen-2-ylpropan-1-amine
  • (3S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
  • (R)-Duloxetine
  • (R)-N-Methyl-3-(1-naphthoxy)-3-(2-thienyl)propylamine
  • (R)-N-Methyl-Gama-(1-Naphthalenyloxy)-2-Thiophenepropanamine
  • (γR)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine
  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-
  • 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (R)-
  • 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, (γR)-
  • 2-thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaR)-
  • See more synonyms
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