CAS 1165910-22-4

4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile

Description:

4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile, with CAS number 1165910-22-4, is a synthetic organic compound characterized by its complex structure featuring multiple functional groups, including a pyrrolidine ring and trifluoromethyl groups. This compound is notable for its trifluoromethyl substituents, which enhance lipophilicity and may influence biological activity. The presence of a benzonitrile moiety suggests potential applications in pharmaceuticals, particularly in the development of compounds with specific receptor interactions. The stereochemistry indicated by the (R) and (S) designations implies that the compound may exhibit chiral properties, which can significantly affect its pharmacokinetics and pharmacodynamics. Additionally, the trifluoroethyl group contributes to the compound's stability and reactivity. Overall, this substance is of interest in medicinal chemistry and may be explored for its potential therapeutic effects, although specific biological activities and safety profiles would require further investigation through empirical studies.

Formula: C₁₄H₁₂F₆N₂O

InChI: InChI=1S/C14H12F6N2O/c15-13(16,17)10-6-9(4-3-8(10)7-21)22-5-1-2-11(22)12(23)14(18,19)20/h3-4,6,11-12,23H,1-2,5H2/t11-,12-/m1/s1

InChI key: InChIKey=OPSIVAKKLQRWKC-VXGBXAGGSA-N

SMILES: [C@@H](C(F)(F)F)(O)[C@@]1(N(CCC1)C2=CC(C(F)(F)F)=C(C#N)C=C2)[H]

Synonyms:

• 4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile
• Benzonitrile, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)-
• Lgd-4033
• Ligandrol
• Vk 5211

Ligandrol

CAS: 1165910-22-4

Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.

Formula: C₁₄H₁₂F₆N₂O

Purity: 99.94% - >99.99%

Color and Shape: Solid

Molecular weight: 338.25

Ref: TM-T15750

LGD-4033

CAS: 1165910-22-4

Applications LGD-4033 is a nonsteroidal oral, selective androgen receptor modulator, in healthy young men.
References Basaria, S., et al.: J. Gerontol A. Biol. Sci. Med. Sci., 68, 87 (2013)

Formula: C₁₄H₁₂F₆N₂O

Color and Shape: White To Light Beige

Molecular weight: 338.25

Ref: TR-L397620

LGD-4033

Controlled Product

CAS: 1165910-22-4

4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile is a potent estrogen receptor modulator (SERM) that binds to the estrogen receptor with high affinity. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. The binding of 4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile to the estrogen receptor is competitive and it can be displaced by estradiol. The drug has a long detection time in urine samples due to its stability and low molecular weight.

Formula: C₁₄H₁₂F₆N₂O

Purity: Min. 95%

Color and Shape: White Beige Powder

Molecular weight: 338.25 g/mol

Ref: 3D-FT102147

Benzonitrile, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)-

CAS: 1165910-22-4

Formula: C₁₄H₁₂F₆N₂O

Purity: 97%

Color and Shape: Solid

Molecular weight: 338.2483

Ref: IN-DA000CU3