Description:Busulfan-D8, also known as Tetramethylene-D8, is a deuterated analog of the chemotherapeutic agent busulfan, which is primarily used in the treatment of certain types of cancers, particularly hematological malignancies. The deuteration (indicated by the "D8") refers to the substitution of hydrogen atoms with deuterium, a stable isotope of hydrogen, which can enhance the compound's stability and alter its pharmacokinetic properties. Busulfan-D8 retains the core structure of busulfan, characterized by its bis(2-chloroethyl) ether moiety, which is crucial for its mechanism of action as an alkylating agent. This compound is utilized in research settings, particularly in studies involving drug metabolism and pharmacodynamics, as well as in the development of targeted therapies. Its CAS number, 116653-28-2, uniquely identifies it in chemical databases. As with other alkylating agents, safety precautions are necessary when handling Busulfan-D8 due to its potential toxicity and the risks associated with exposure.
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