CAS 116653-28-2

BUSULFAN-D8 (TETRAMETHYLENE-D8)

Description:

Busulfan-D8, also known as Tetramethylene-D8, is a deuterated analog of the chemotherapeutic agent busulfan, which is primarily used in the treatment of certain types of cancers, particularly hematological malignancies. The deuteration (indicated by the "D8") refers to the substitution of hydrogen atoms with deuterium, a stable isotope of hydrogen, which can enhance the compound's stability and alter its pharmacokinetic properties. Busulfan-D8 retains the core structure of busulfan, characterized by its bis(2-chloroethyl) ether moiety, which is crucial for its mechanism of action as an alkylating agent. This compound is utilized in research settings, particularly in studies involving drug metabolism and pharmacodynamics, as well as in the development of targeted therapies. Its CAS number, 116653-28-2, uniquely identifies it in chemical databases. As with other alkylating agents, safety precautions are necessary when handling Busulfan-D8 due to its potential toxicity and the risks associated with exposure.

Formula: C₆H₆D₈O₆S₂

InChI: InChI=1/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3/i3D2,4D2,5D2,6D2

SMILES: CS(=O)(=O)OC(C(C(C(OS(=O)(=O)C)([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H]

Synonyms:

• Busulfan-D8(tetramethylene)
• 1,4-Butanediol-d8-dimethanesulfonate Esters
• Busulfan-d8
• Busulfex-d8
• Busulphan-d8
• CB-2041-d8
• GT-41-d8

Busulfan-d8(tetramethylene-d8)

CAS: 116653-28-2

Formula: CH₃SO₂O(CD₂)₄OSO₂CH₃

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 254.07339

Ref: 3U-D6067

Busulfan-d8

CAS: 116653-28-2

Busulfan-d8 (Sulphabutin-d8) is the 2H-labeled Busulfan. Busulfan is an anticancer agent with immunosuppressive and myeloablative chemotherapy activities.

Formula: C₆H₆D₈O₆S₂

Color and Shape: Solid

Molecular weight: 254.35

Ref: TM-TMID-0076

Busulfan-d8

CAS: 116653-28-2

Formula: C₆H₆D₈O₆S₂

Molecular weight: 254.34

Ref: 4Z-B-068007

Busulfan-d8

Controlled Product

CAS: 116653-28-2

Applications Alkylating agent with antileukemic activity. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ehrsson, H., et al.: Clin. Pharmacol. Ther., 34, 86 (1983), Bishop, J.B., et al.: Mutat. Res., 168,15 (1986), Tariq, M., et al.: Anal. Profiles Drug Subs., 16, 53 (1987),

Formula: C₆₂H₈H₆O₆S₂

Color and Shape: White Solid

Molecular weight: 254.35

Ref: TR-B689902

1,4-Butane-1,1,2,2,3,3,4,4-d8-diol, dimethanesulfonate (9CI)

CAS: 116653-28-2

Formula: C₆H₆D₈O₆S₂

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 254.3511

Ref: IN-DA000CXJ