CAS 116666-63-8: Mibefradil dihydrochloride

Description: Mibefradil dihydrochloride is a chemical compound primarily recognized for its role as a calcium channel blocker, which was initially developed for the treatment of hypertension and angina. It functions by inhibiting specific calcium channels, leading to vasodilation and reduced cardiac workload. The compound is characterized by its dihydrochloride salt form, which enhances its solubility in water, facilitating its pharmacological applications. Mibefradil exhibits a unique mechanism of action, selectively blocking T-type calcium channels, which distinguishes it from other calcium channel blockers. Its chemical structure includes a complex arrangement of aromatic and aliphatic groups, contributing to its biological activity. However, its clinical use has been limited due to safety concerns, particularly regarding drug interactions and adverse effects. As a result, mibefradil dihydrochloride is not widely prescribed today, but it remains of interest in pharmacological research for its unique properties and potential applications in other therapeutic areas.

Formula: C₂₉H₃₈FN₃O₃·2ClH

InChI: InChI=1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H/t28-,29-;;/m0../s1

InChI key: InChIKey=MTJLQTFHJIHXIX-GDUXWEAWSA-N

SMILES: Cl.O=C(OC1(CCC2=CC(F)=CC=C2C1C(C)C)CCN(C)CCCC3=NC=4C=CC=CC4N3)COC

Synonyms:

• (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate dihydrochloride
• (1S-Cis)-Orid
• 2-(2-((3-(1H-Benzimidazol-2-Yl)Propyl)Methylamino)Ethyl)-Aceticaci
• 6-Fluoro-1,2,3,4-Tetrahydro-1-(1-Methylethyl)-2-Naphthalenylester,Dihydrochl
• Acetic acid, 2-methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)
• Acetic acid, methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride
• Acetic acid, methoxy-, 2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, dihydrochloride, (1S-cis)-
• Mibefradil diHCl
• Mibefradil dihydrochloride
• Mibefradil hydrate dihydrochloride
• Posicor
• Ro 40-5967
• Ro 40-5967 hydrate, (1S,2S)-2-[2[[3-(2-Benzimidazolylpropyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate hydrate dihydrochloride
• Ro 40-5967/001
• Ro40-5967/001

Acetic acid, 2-methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2)

CAS: 116666-63-8

• Formula: C₂₉H₄₀Cl₂FN₃O₃
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 568.5506

Mibefradil dihydrochloride

CAS: 116666-63-8

• Formula: C₂₉H₃₈FN₃O₃· 2HCl·xH₂O
• Molecular weight: 568.55 (anhydrous)

Mibefradil dihydrochloride

CAS: 116666-63-8

Mibefradil dihydrochloride (Ro 40-5967 (dihydrochloride)) is an blocker of calcium channel with moderate selectivity for …

• Formula: C₂₉H₄₀Cl₂FN₃O₃
• Purity: 99.45% - 99.72%
• Color and Shape: Solid
• Molecular weight: 568.55

Mibefradil hydrochloride

CAS: 116666-63-8

Mibefradil is a calcium channel antagonist with the highest selectivity for T- and L-type channels, …

• Formula: C₂₉H₃₈FN₃O₃·2HCl
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 568.55 g/mol

Mibefradil Dihydrochloride

CAS: 116666-63-8

Applications Mibefradil dihydrochloride is selectively blocks Ca2+ entry into cells by inhibiting T-type Ca2+ channels.

• Formula: C₂₉H₃₈FN₃O₃· 2HCl
• Purity: >90%
• Color and Shape: Neat
• Molecular weight: 568.55