CAS 1167421-25-1

Nε-2-Azidoethyloxycarbonyl-L-lysine

Description:

Nε-2-Azidoethyloxycarbonyl-L-lysine is a modified amino acid derivative of lysine, characterized by the presence of an azido group and an ethyloxycarbonyl moiety. This compound typically features a primary amine group, which is characteristic of lysine, allowing for potential reactivity in various chemical reactions, particularly in bioconjugation and click chemistry applications. The azido group (-N3) is known for its ability to participate in azide-alkyne cycloaddition reactions, making this compound valuable in the synthesis of complex biomolecules and in the development of bioconjugates. The ethyloxycarbonyl group serves as a protective group, enhancing the stability and solubility of the molecule in various solvents. Overall, Nε-2-Azidoethyloxycarbonyl-L-lysine is a versatile compound used in chemical biology and medicinal chemistry for its unique reactivity and functionalization potential. Its applications may include drug delivery systems, protein labeling, and the study of protein interactions.

Formula: C₉H₁₇N₅O₄

Synonyms:

• Nε-2-Azidoethyloxycarbonyl-L-lysine
• (S)-2-Amino-6-((2-azidoethoxy)carbonylamino)hexanoic acid
• N3-Lys
• Nε-2-AzidoethyL
• N6-[(2-Azidoethoxy)carbonyl]-L-lysine
• Click-Amino-Acid / N3-Lys
• UAA crosslinker 1
• (2S)-2-amino-6-{[(2-azidoethoxy)carbonyl]amino}hexanoic acid
• (S)-2-amino-6-((2-azidoethoxy)carbonylamino)hexanoic acid hydrochloride
• -2-Azidoethyloxycarbonyl-L-lysine

(2S)-2-amino-6-{[(2-azidoethoxy)carbonyl]amino}hexanoic acid

CAS: 1167421-25-1

Formula: C₉H₁₇N₅O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 259.2624

Ref: IN-DA0096R4

N6-((2-Azidoethoxy)carbonyl)-L-lysine

CAS: 1167421-25-1

N6-((2-Azidoethoxy)carbonyl)-L-lysine

Purity: 95%

Molecular weight: 259.27g/mol

Ref: 54-OR1053113

UAA crosslinker 1

CAS: 1167421-25-1

UAA crosslinker 1 hydrochloride enables in vivo ncAAs incorporation into proteins via wildtype/engineered aminoacyl-tRNA synthetases.

Formula: C₉H₁₇N₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 259.26

Ref: TM-T18864

Nε-2-Azidoethyloxycarbonyl-L-lysine

Controlled Product

CAS: 1167421-25-1

Stability Light Sensitive
Applications Nε-2-Azidoethyloxycarbonyl-L-lysine is derived from 2-Azidoethanol (A848560), which is used as a reagent in the glycosylation of mono- or polysaccharides. 2-Azidoethanol is also used as a 2’-deoxy-ethynyluridine (EdU) blocker in nuclear DNA, preventing cross relativity with other antibodies in order to better study its related pathways in the body.
References Liboska, R., et al.: PLOS ONE, 7, e51679 (2012); Sun, X., et al.: Biomacromolecules, 3, 1065 (2002)

Formula: C₉H₁₇N₅O₄

Color and Shape: Neat

Molecular weight: 259.26

Ref: TR-A848920

N6-[(2-Azidoethoxy)carbonyl]-l-lysine

CAS: 1167421-25-1

N6-[(2-Azidoethoxy)carbonyl]-l-lysine is a triazole that is chemically synthesized. It has been used to label recombinant proteins and it can be used as a fluorescent probe for labeling DNA or RNA. N6-[(2-Azidoethoxy)carbonyl]-l-lysine can be used to introduce site-specific intramolecular crosslinks in proteins by reacting with an amine group on the protein and a nucleophilic group on the same protein. This chemical reaction results in the formation of a covalent bond between two amino acid residues, causing a change in the topology of the protein. The introduction of this chemical moiety into erythromycin A was shown to decrease its antibiotic activity against Gram-positive bacteria such as Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, and Enterococcus faecium.

Formula: C₉H₁₇N₅O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 259.26 g/mol

Ref: 3D-FA178291