Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase that plays a crucial role in various cellular processes, particularly in the nervous system and cardiac muscle. The specific fragment referred to as "CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)" likely represents a portion of the protein that is involved in its regulatory mechanisms. This kinase is activated by the binding of calcium-bound calmodulin, leading to autophosphorylation and subsequent activation of its kinase activity. CaMKII is known for its role in synaptic plasticity, learning, and memory, as well as in the regulation of cardiac contractility. The CAS number 116826-37-0 identifies a specific chemical entity, which may refer to a synthetic or modified form of this protein fragment used in research. Characteristics of this substance may include its molecular weight, solubility in various solvents, and stability under different conditions, which are essential for its application in biochemical studies. Understanding its structure and function is vital for exploring its potential therapeutic implications in neurological and cardiovascular diseases.

CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)

116826-37-0: Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase that plays a crucial role in various cellular processes, particularly in the nervous system and cardiac muscle. The specific fragment referred to as "CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)" likely represents a portion of the protein that is involved in its regulatory mechanisms. This kinase is activated by the binding of calcium-bound calmodulin, leading to autophosphorylation and subsequent activation of its kinase activity. CaMKII is known for its role in synaptic plasticity, learning, and memory, as well as in the regulation of cardiac contractility. The CAS number 116826-37-0 identifies a specific chemical entity, which may refer to a synthetic or modified form of this protein fragment used in research. Characteristics of this substance may include its molecular weight, solubility in various solvents, and stability under different conditions, which are essential for its application in biochemical studies. Understanding its structure and function is vital for exploring its potential therapeutic implications in neurological and cardiovascular diseases.

Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).

CAS 116826-37-0

CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)

Calmodulin-Dependent Protein Kinase II (281-309)

Ref: TM-TP1716