CAS 116970-50-4

5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, hydrochloride (1:1)

Description:

5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, hydrochloride (1:1) is a chemical compound characterized by its isoquinoline structure, which is a bicyclic aromatic compound. This substance features a sulfonamide functional group, contributing to its potential biological activity, particularly in medicinal chemistry. The presence of the aminoethyl side chain enhances its solubility and reactivity, making it suitable for various applications, including as a pharmacological agent. The hydrochloride form indicates that the compound is a salt, which typically improves stability and solubility in aqueous solutions. This compound may exhibit properties such as inhibition of specific enzymes or receptors, making it of interest in drug development, particularly in the context of treating diseases related to the central nervous system or cancer. As with many sulfonamides, it may also possess antibacterial properties. Safety and handling precautions are essential due to potential toxicity, and its use should be guided by appropriate regulatory standards.

Formula: C₁₁H₁₃N₃O₂S·ClH

InChI: InChI=1S/C11H13N3O2S.ClH/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11;/h1-4,6,8,14H,5,7,12H2;1H

InChI key: InChIKey=ZAMCOVXWUOADQX-UHFFFAOYSA-N

SMILES: S(NCCN)(=O)(=O)C=1C2=C(C=CC1)C=NC=C2.Cl

Synonyms:

• 5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, hydrochloride (1:1)
• 5-Isoquinolinesulfonamide, N-(2-aminoethyl)-, monohydrochloride
• N-(2-Aminoethyl)-5-Isoquinolinesulfonamide Hydrochloride
• N-(2-Aminoethyl)-5-Isoquinolinesulfonamidemonohydrochloride
• N-(2-Aminoethyl)-5-Isoquinolinesulfonamidmonohydrochloride
• N-(2-Aminoethyl)-5-isoquinolinesulfonamide, Dihydrochloride Discontinued See: A609001
• N-(2-Aminoethyl)-Isochinoline-5-Sulfonamide Hydrochloride
• N-(2-Aminoethyl)Isoquinoline-5-Sulfonamide Hydrochloride
• N-(2-Aminoethyl)Isoquinoline-5-Sulfonamide Hydrochloride (H9)

H-9

CAS: 116970-50-4

Formula: C₁₁H₁₄ClN₃O₂S

Purity: 97%

Color and Shape: Solid

Molecular weight: 287.7658

Ref: IN-DA008S1H

N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride

CAS: 116970-50-4

N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride

Purity: 97%

Molecular weight: 287.77g/mol

Ref: 54-OR1068746

N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride (H9)

CAS: 116970-50-4

Ref: 7W-GE8296

N-(2-Aminoethyl)isoquinoline-5-sulfonamide hydrochloride

CAS: 116970-50-4

Formula: C₁₁H₁₄ClN₃O₂S

Purity: 97%

Molecular weight: 287.76

Ref: 10-F540183

N-(2-Aminoethyl)-5-isoquinolinesulfonamide Hydrochloride

Controlled Product

CAS: 116970-50-4

Applications A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP.
References Hidaka, H., et al.: J. Biol. Chem., 260, 5, 2922 (1985),

Formula: C₁₁H₁₃N₃O₂S·ClH

Color and Shape: Neat

Molecular weight: 287.77

Ref: TR-A609001

H-9 hydrochloride

CAS: 116970-50-4

H-9 hydrochloride is a selective protein kinase inhibitor, which is synthetically derived. It primarily inhibits cyclic nucleotide-dependent protein kinases, including protein kinase A (PKA) and protein kinase G (PKG), along with myosin light chain kinase (MLCK). The mode of action involves competitive inhibition at the ATP binding site of these kinases, thereby impacting phosphorylation pathways crucial for multiple physiological functions. The selective inhibition by H-9 hydrochloride allows for detailed exploration of kinase-mediated signaling pathways in cellular biology. Moreover, it is extensively utilized in studies involving cell motility, smooth muscle contraction, and signal transduction. The relevance of H-9 hydrochloride in academic research lies in its ability to provide insights into kinase activity modulation and its ensuing effects on cellular dynamics. This compound serves as an invaluable tool for scientists aiming to elucidate the complex role of protein kinases in health and disease, enabling the development of innovative therapeutic strategies.

Formula: C₁₁H₁₄ClN₃O₂S

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 287.77 g/mol

Ref: 3D-FA17738