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CAS 117032-52-7

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N(4)-(N-(6-trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-dimethoxytrityl-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite

Description:
The chemical substance N(4)-(N-(6-trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-dimethoxytrityl-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite, with CAS number 117032-52-7, is a modified nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features a deoxycytidine base, which is a nucleobase component of DNA, and is modified with a dimethoxytrityl (DMT) protecting group at the 5' position, enhancing its stability and solubility during synthesis. The presence of a phosphoramidite group at the 3' position allows for efficient coupling reactions in automated oligonucleotide synthesis. Additionally, the trifluoroacetylamide moiety contributes to the compound's solubility and reactivity. The structural modifications, including the aminoethyl and caproyl linkers, are designed to improve the compound's properties for specific applications in molecular biology, such as gene therapy and antisense oligonucleotide development. Overall, this compound exemplifies the complexity and specificity required in the design of nucleic acid analogs for advanced biotechnological applications.
Formula:C48H64F3N6O10P
InChI:InChI=1/C48H64F3N6O10P/c1-32(2)57(46(4,5)6)68(61,62)67-41-39(31-65-47(34-16-12-11-13-17-34,35-18-22-37(63-7)23-19-35)36-20-24-38(64-8)25-21-36)66-43(40(41)58)56-30-33(3)42(55-45(56)60)53-29-28-52-26-14-9-10-15-27-54-44(59)48(49,50)51/h11-13,16-26,30,32,39-41,43,58H,9-10,14-15,27-29,31H2,1-8H3,(H,54,59)(H,61,62)(H,53,55,60)/b52-26+/t39-,40-,41-,43-/m1/s1
Synonyms:
  • N4-Tadmd
  • N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-dimethoxytrityl-2'-deoxy-5-methylcytidine-3'-N,N-diisopropylmethylphosphoramidite
  • N(4)-Tadmd
  • Cytidine, 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-5-methyl-N-(2-((1-oxo-6-((trifluoroacetyl)amino)hexyl)amino)ethyl)-, 3'-(methyl bis(1-methylethyl)phosphoramidate)
  • 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-{[tert-butyl(1-methylethyl)amino](hydroxy)phosphoryl}-5-methyl-N-[2-({(1E)-6-[(trifluoroacetyl)amino]hexylidene}amino)ethyl]cytidine
  • N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-dimethoxytrityl-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite
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  • N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine-3'-N,N-di…
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    N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite

    CAS:
    <p>N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine-3'-N,N-diisopropylmethylphosphoramidite (CAS No. 117032-52-7) is a novel anticancer, antiviral and high quality ribonucleoside phosphoramidite. The product is chemically modified to avoid the incorporation of radioactive isotopes and can be used in DNA synthesis for research purposes. N(4)-(N-(6-Trifluoroacetylamidocaproyl)-2-aminoethyl)-5'-O-DMT-5-methyl-2'-deoxycytidine 3'-N,N-diisopropylmethylphosphoramidite has been shown to inhibit the replication of RNA virus in vitro</p>
    Formula:C48H64F3N6O10P
    Purity:Min. 95%
    Molecular weight:973.03 g/mol

    Ref: 3D-PT103881

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