CAS 117048-59-6
:Combretastatin A4
Description:
Combretastatin A4 is a naturally occurring compound derived from the bark of the Combretum caffrum tree, known for its potent anti-cancer properties. It belongs to the class of stilbenes and is recognized for its ability to inhibit tubulin polymerization, thereby disrupting the formation of microtubules, which are essential for cell division. This mechanism makes it a promising candidate for cancer therapy, particularly in targeting solid tumors. The compound exhibits a relatively low molecular weight and is characterized by its specific structural features, including a trans-stilbene configuration. Combretastatin A4 has shown significant cytotoxicity against various cancer cell lines in preclinical studies. Additionally, it has been investigated for its potential to enhance the efficacy of other chemotherapeutic agents and to induce tumor vascular collapse, leading to reduced tumor blood supply. However, its clinical application is limited by factors such as solubility and stability, prompting ongoing research into its derivatives and formulations to improve therapeutic outcomes.
Formula:C18H20O5
InChI:InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChI key:InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N
SMILES:O(C)C1=C(OC)C=C(/C=C\C2=CC(O)=C(OC)C=C2)C=C1OC
Synonyms:- (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
- (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
- 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
- 2′-Deoxycombretastatin A1
- C 7744
- Ca-4
- Cis-Combretastatin A4
- Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
- Combretastatin
- Combretastatin 4
- Combretastatin A<sub>4</sub>
- CombretastatinA4
- Crc 87-09
- NSC 613729
- NSC 817373
- Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
- Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, (Z)-
- Combretastatin A4
- See more synonyms
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Found 12 products.
Combretastatin A4
CAS:Formula:C18H20O5Purity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:316.35Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
CAS:Formula:C18H20O5Purity:98%Color and Shape:SolidMolecular weight:316.3484Combretastatin A4-13C-d3
CAS:Formula:C1713CH17D3O5Color and Shape:Off-White SolidMolecular weight:320.36(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol
CAS:(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)PhenolPurity:98%Molecular weight:316.35g/molCombretastatin A4
CAS:Formula:C18H20O5Purity:≥ 97.5%Color and Shape:White to off-white, beige or pale yellow powder or solidMolecular weight:316.35Combretastatin A4
CAS:<p>Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).</p>Formula:C18H20O5Purity:99.24% - 99.56%Color and Shape:Crystalline PowderMolecular weight:316.35Combretastatin A4
CAS:Formula:C18H20O5Purity:98%Color and Shape:Solid, White - Almost white powderMolecular weight:316.353Combretastatin A4
CAS:<p>Tubulin binding agent; targets tumour vasculature</p>Formula:C18H20O5Purity:Min. 95%Molecular weight:316.35 g/mol
![Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000DMO.jpg&w=3840&q=75)
