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CAS 117048-59-6

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Combretastatin A4

Description:
Combretastatin A4 is a naturally occurring compound derived from the bark of the Combretum caffrum tree, known for its potent anti-cancer properties. It belongs to the class of stilbenes and is recognized for its ability to inhibit tubulin polymerization, thereby disrupting the formation of microtubules, which are essential for cell division. This mechanism makes it a promising candidate for cancer therapy, particularly in targeting solid tumors. The compound exhibits a relatively low molecular weight and is characterized by its specific structural features, including a trans-stilbene configuration. Combretastatin A4 has shown significant cytotoxicity against various cancer cell lines in preclinical studies. Additionally, it has been investigated for its potential to enhance the efficacy of other chemotherapeutic agents and to induce tumor vascular collapse, leading to reduced tumor blood supply. However, its clinical application is limited by factors such as solubility and stability, prompting ongoing research into its derivatives and formulations to improve therapeutic outcomes.
Formula:C18H20O5
InChI:InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChI key:InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N
SMILES:O(C)C1=C(OC)C=C(/C=C\C2=CC(O)=C(OC)C=C2)C=C1OC
Synonyms:
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
  • (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
  • 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
  • 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
  • 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
  • 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
  • 2′-Deoxycombretastatin A1
  • C 7744
  • Ca-4
  • Cis-Combretastatin A4
  • See more synonyms
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