CAS 117048-59-6: Combretastatin A4

Description: Combretastatin A4 is a naturally occurring compound derived from the bark of the Combretum caffrum tree, known for its potent anti-cancer properties. It belongs to the class of stilbenes and is recognized for its ability to inhibit tubulin polymerization, thereby disrupting the formation of microtubules, which are essential for cell division. This mechanism makes it a promising candidate for cancer therapy, particularly in targeting solid tumors. The compound exhibits a relatively low molecular weight and is characterized by its specific structural features, including a trans-stilbene configuration. Combretastatin A4 has shown significant cytotoxicity against various cancer cell lines in preclinical studies. Additionally, it has been investigated for its potential to enhance the efficacy of other chemotherapeutic agents and to induce tumor vascular collapse, leading to reduced tumor blood supply. However, its clinical application is limited by factors such as solubility and stability, prompting ongoing research into its derivatives and formulations to improve therapeutic outcomes.

Formula: C₁₈H₂₀O₅

InChI: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-

InChI key: InChIKey=HVXBOLULGPECHP-WAYWQWQTSA-N

SMILES: OC1=CC(=CC=C1OC)C=CC2=CC(OC)=C(OC)C(OC)=C2

Synonyms:

• (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
• (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
• 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
• 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
• 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
• 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
• 2′-Deoxycombretastatin A1
• C 7744
• Ca-4
• Cis-Combretastatin A4
• Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
• Combretastatin
• Combretastatin 4
• Combretastatin A₄
• CombretastatinA4
• Crc 87-09
• NSC 613729
• NSC 817373
• Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
• Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, (Z)-
• Combretastatin A4
• Combretastatin/A-4

Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 316.3484

Combretastatin A4-13C-d3

CAS: 117048-59-6

• Formula: C₁₇₁₃CH₁₇D₃O₅
• Color and Shape: Off-White Solid
• Molecular weight: 320.36

(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol

CAS: 117048-59-6

• Purity: 98%+
• Molecular weight: 316.35g/mol

Combretastatin A4

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Purity: 95%~99%
• Molecular weight: 316.353

Combretastatin A4

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 316.35

Combretastatin A4

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Molecular weight: 316.36

Combretastatin A4

CAS: 117048-59-6

Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).

• Formula: C₁₈H₂₀O₅
• Purity: 98.21% - 99.81%
• Color and Shape: Crystalline Powder
• Molecular weight: 316.35

Combretastatin A4

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Purity: ≥ 97.5%
• Color and Shape: White to off-white, beige or pale yellow powder or solid
• Molecular weight: 316.35

Combretastatin A4

CAS: 117048-59-6

• Purity: 98.0%
• Color and Shape: Solid, White - Almost white powder
• Molecular weight: 316.3529968261719

Combretastatin A4

CAS: 117048-59-6

• Formula: C₁₈H₂₀O₅
• Color and Shape: Neat
• Molecular weight: 316.35

Combretastatin A4

CAS: 117048-59-6

Tubulin binding agent; targets tumour vasculature

• Formula: C₁₈H₂₀O₅
• Purity: Min. 95%
• Molecular weight: 316.35 g/mol