CAS 1171-81-9

16α-Hydroxycortisol

Description:

16α-Hydroxycortisol, with the CAS number 1171-81-9, is a steroid hormone that is a derivative of cortisol, specifically characterized by the hydroxyl group at the 16α position. This compound is classified as a glucocorticoid and is involved in various physiological processes, including the regulation of metabolism and immune response. It is primarily produced in the adrenal glands and plays a role in the metabolism of carbohydrates, proteins, and fats. The substance exhibits anti-inflammatory properties and is involved in the body's stress response. In terms of its chemical structure, 16α-Hydroxycortisol has a steroid backbone, which is typical of glucocorticoids, and its molecular formula reflects the presence of hydroxyl groups that influence its biological activity. This compound is of interest in clinical and research settings, particularly in the study of adrenal function and disorders related to cortisol metabolism. Its measurement can be significant in diagnosing conditions such as Cushing's syndrome or adrenal insufficiency.

Formula: C₂₁H₃₀O₆

InChI: InChI=1S/C21H30O6/c1-19-6-5-12(23)7-11(19)3-4-13-14-8-16(25)21(27,17(26)10-22)20(14,2)9-15(24)18(13)19/h7,13-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t13-,14-,15-,16+,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=SQPRYYSTJMNHSK-ILNISADRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(C[C@@H](O)[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (11Beta,16Alpha)-11,16,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione
• (11β,16α)-11,16,17,21-Tetrahydroxypregn-4-ene-3,20-dione
• 1171-81-9
• 16α-Hydroxycortisol
• Corticosterone, 16α,17-dihydroxy-
• Pregn-4-ene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-
• Pregn-4-ene-3,20-dione, 11β,16α,17,21-tetrahydroxy-
• U 34908

Budesonide Impurity 10

CAS: 1171-81-9

Formula: C₂₁H₃₀O₆

Color and Shape: White To Off-White Solid

Molecular weight: 378.47

Ref: 4Z-B-0342

16α-Hydroxycortisol

Controlled Product

CAS: 1171-81-9

Applications 11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione is a metabolite of Hydroxycortisone (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Formula: C₂₁H₃₀O₆

Color and Shape: Neat

Molecular weight: 378.46

Ref: TR-H922280

16a-Hydroxycortisol

Controlled Product

CAS: 1171-81-9

16a-Hydroxycortisol is a naturally occurring, prednisolone metabolite. It binds to the mineralocorticoid receptor in target tissues and has been shown to have high affinity binding with cytosolic proteins. 16a-Hydroxycortisol can be used as a binder in the manufacture of steroid hormone drugs.

Formula: C₂₁H₃₀O₆

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 378.46 g/mol

Ref: 3D-FH165346

16α-Hydroxycortisol

CAS: 1171-81-9

Formula: C₂₁H₃₀O₆

Molecular weight: 378.47

Ref: ST-EA-CP-B19027