CAS 1173-13-3

Previtamin D3

Description:

Previtamin D3, also known as 7-dehydrocholesterol, is a sterol compound that plays a crucial role in the biosynthesis of vitamin D in the human body. It is primarily found in the skin and is synthesized from cholesterol upon exposure to ultraviolet B (UVB) radiation from sunlight. The chemical structure of previtamin D3 includes a steroid backbone, which is characteristic of sterols, and it undergoes a thermal isomerization process to convert into vitamin D3 (cholecalciferol) when exposed to heat. Previtamin D3 is a colorless to pale yellow solid at room temperature and is insoluble in water but soluble in organic solvents. Its biological significance lies in its conversion to vitamin D3, which is essential for calcium homeostasis and bone health. Deficiencies in vitamin D can lead to various health issues, including rickets in children and osteomalacia in adults. The compound is also of interest in research related to skin health and the effects of UV radiation.

Formula: C₂₇H₄₄O

InChI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26+,27-/m1/s1

InChI key: InChIKey=YUGCAAVRZWBXEQ-WHTXLNIXSA-N

SMILES: C[C@@]12[C@](C(/C=C\C3=C(C)CC[C@H](O)C3)=CCC1)(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Synonyms:

• (1S)-3-[(1Z)-2-[(1R,3aR,7aR)-1-[(1R)-1,5-Dimethylhexyl]-2,3,3a,6,7,7a-hexahydro-7a-methyl-1H-inden-4-yl]ethenyl]-4-methyl-3-cyclohexen-1-ol
• (1S)-3-[2-[(1R,3aR,7aR)-1-[(1R)-1,5-dimethylhexyl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]vinyl]-4-methyl-cyclohex-3-en-1-ol
• (3S,6Z,14β)-9,10-secocholesta-5(10),6,8-trien-3-ol
• (3beta,6Z)-9,10-Secocholesta-5(10),6,8-trien-3-ol
• 3-Cyclohexen-1-ol, 3-[(1Z)-2-[(1R,3aR,7aR)-1-[(1R)-1,5-dimethylhexyl]-2,3,3a,6,7,7a-hexahydro-7a-methyl-1H-inden-4-yl]ethenyl]-4-methyl-, (1S)-
• 9,10-Secocholesta-5(10),6,8-trien-3-ol, (3β,6Z)-
• 9,10-Secocholesta-5(10),6,8-trien-3β-ol
• Precalciferol
• Precalciferol₃
• Precholecalciferol
• Previtamin D
• Previtamin D(3)
• Previtamin D₃

Previtamin D3

CAS: 1173-13-3

Previtamin D3

Purity: 80%

Molecular weight: 384.64g/mol

Ref: 54-OR1075432

Precalciferol (Previtamin D3)

CAS: 1173-13-3

Formula: C₂₇H₄₄O

Molecular weight: 384.65

Ref: 4Z-C-5110

Previtamin D3

CAS: 1173-13-3

Previtamin D3 is an intermediate in the production of cholecalciferol (vitamin D3).

Formula: C₂₇H₄₄O

Color and Shape: Solid

Molecular weight: 384.648

Ref: TM-T38553

Previtamin D3 (>80%)

Controlled Product

CAS: 1173-13-3

Stability Light Sensitive, Temperature Sensitive
Applications Vitamin D3 (V676045) isomer. Vitamin D3 mediates intestinal calcium absorbtion, bone calcium metabolism and many other processes. During exposure to sunlight 7-dehydrocholesterol in converted to pre-vitamin D3, which undergoes a rapid transformation within the plasma membrane to vitamin D3.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Holick, M. et al.; J. Bone. Miner. Metab. 22, V28 (2007); Tian, X. & Holick, M.; J. Biol. Chem. 270, 8706 (1995)

Formula: C₂₇H₄₄O

Purity: >80%

Color and Shape: Colourless

Molecular weight: 384.64

Ref: TR-P713510

Precholecalciferol

CAS: 1173-13-3

Precholecalciferol is a vitamin D analog that has been shown to be active in the target tissue. It is used for the treatment of chronic kidney disease and autoimmune diseases, including multiple sclerosis. The activated form of this drug is converted to calcitriol by hydroxylation, which is then metabolized by the liver. This form of the drug can also be converted by epoxide hydrolase to 25-hydroxycholecalciferol, which can be further metabolized by cytochrome P450 enzymes to 1,25-dihydroxycholecalciferol (1,25-(OH)2D3). This form of the drug can bind to nuclear receptors and activate gene transcription. Precholecalciferol has been shown to activate growth factors such as insulin-like growth factor-I and platelet-derived growth factor, which may contribute to its role in treating autoimmune diseases.

Formula: C₂₇H₄₄O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.64 g/mol

Ref: 3D-FP159099