Immunoglobulin Fab fragments are derived from antibodies and consist of the variable regions of the heavy and light chains, which are responsible for antigen binding. The specific substance you mentioned, with CAS number 117305-33-6, is a complex protein that includes a mouse monoclonal T101 heavy chain linked via disulfide bonds to a mouse monoclonal T101 light chain, as well as being disulfide-linked to the ricin A-chain, a toxic protein derived from the castor bean. This structure allows the Fab fragment to retain its antigen-binding capability while also incorporating the toxic properties of ricin, which can inhibit protein synthesis in cells. The presence of disulfide bonds is crucial for maintaining the structural integrity and functional conformation of the protein. Such constructs are often used in research and therapeutic applications, particularly in targeted drug delivery systems, where the specificity of the antibody can direct the toxic effects of ricin to specific cells or tissues.

Immunoglobulin, Fab fragment (mouse monoclonal T101 heavy chain), disulfide with mouse monoclonal T101 light chain, disulfide with ricin (castor bean A-chain)

117305-33-6: Immunoglobulin Fab fragments are derived from antibodies and consist of the variable regions of the heavy and light chains, which are responsible for antigen binding. The specific substance you mentioned, with CAS number 117305-33-6, is a complex protein that includes a mouse monoclonal T101 heavy chain linked via disulfide bonds to a mouse monoclonal T101 light chain, as well as being disulfide-linked to the ricin A-chain, a toxic protein derived from the castor bean. This structure allows the Fab fragment to retain its antigen-binding capability while also incorporating the toxic properties of ricin, which can inhibit protein synthesis in cells. The presence of disulfide bonds is crucial for maintaining the structural integrity and functional conformation of the protein. Such constructs are often used in research and therapeutic applications, particularly in targeted drug delivery systems, where the specificity of the antibody can direct the toxic effects of ricin to specific cells or tissues.

Telimomab aritox (T101-ricin A chain immunotoxin) is a mouse monoclonal antibody fused to the A chain of ricin protein, functioning as an immunosuppressive

CAS 117305-33-6

Immunoglobulin, Fab fragment (mouse monoclonal T101 heavy chain), disulfide with mouse monoclonal T101 light chain, disulfide with ricin (castor bean A-chain)

Telimomab aritox

Ref: TM-T81021

Telimomab aritox

Ref: 3D-CLA1239