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CAS 117346-20-0

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12-hydroxy-5,8,14-eicosatrienoic acid

Description:
12-Hydroxy-5,8,14-eicosatrienoic acid, commonly referred to as 12-HETE, is a bioactive lipid belonging to the family of hydroxy fatty acids. It is characterized by a long carbon chain with a total of 20 carbon atoms and three double bonds, indicating its polyunsaturated nature. The presence of a hydroxyl group at the 12th carbon position is significant for its biological activity. This compound is known to play a role in various physiological processes, including inflammation, cell signaling, and vascular function. It is produced through the enzymatic action of lipoxygenases on arachidonic acid and is involved in the modulation of immune responses. 12-HETE can influence cell proliferation, migration, and differentiation, making it a subject of interest in research related to cancer and cardiovascular diseases. Its CAS number, 117346-20-0, is a unique identifier that facilitates the tracking and study of this compound in scientific literature and databases. Overall, 12-HETE is an important mediator in lipid metabolism and cellular communication.
Formula:C20H34O3
InChI:InChI=1/C20H34O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13,19,21H,2-6,12,14-18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-/t19-/m0/s1
SMILES:CCCCC/C=C\C[C@@H](CC/C=C\C/C=C\CCCC(=O)O)O
Synonyms:
  • 12(R)DH-Hete
  • 5,8,14-Eicosatrienoic acid, 12-hydroxy-, (R-(Z,Z,Z))-
  • (5Z,8Z,12R,14Z)-12-hydroxyicosa-5,8,14-trienoic acid
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