Brodalumab is a monoclonal antibody that specifically targets the interleukin-17 receptor A (IL-17RA), playing a significant role in the immune response and inflammation. It is primarily used in the treatment of moderate to severe plaque psoriasis and has shown efficacy in reducing symptoms associated with this condition. The molecular structure of brodalumab consists of a human IgG2 antibody framework, which enhances its stability and reduces immunogenicity. Its mechanism of action involves blocking the interaction of IL-17A with its receptor, thereby inhibiting the inflammatory pathways that contribute to psoriasis. Brodalumab is administered via subcutaneous injection and has a relatively long half-life, allowing for less frequent dosing. Common side effects may include injection site reactions, headache, and an increased risk of infections due to its immunomodulatory effects. As with any biologic therapy, careful monitoring for adverse effects and contraindications is essential during treatment. Overall, brodalumab represents a targeted therapeutic option in the management of autoimmune skin disorders.

Brodalumab

1174395-19-7: Brodalumab is a monoclonal antibody that specifically targets the interleukin-17 receptor A (IL-17RA), playing a significant role in the immune response and inflammation. It is primarily used in the treatment of moderate to severe plaque psoriasis and has shown efficacy in reducing symptoms associated with this condition. The molecular structure of brodalumab consists of a human IgG2 antibody framework, which enhances its stability and reduces immunogenicity. Its mechanism of action involves blocking the interaction of IL-17A with its receptor, thereby inhibiting the inflammatory pathways that contribute to psoriasis. Brodalumab is administered via subcutaneous injection and has a relatively long half-life, allowing for less frequent dosing. Common side effects may include injection site reactions, headache, and an increased risk of infections due to its immunomodulatory effects. As with any biologic therapy, careful monitoring for adverse effects and contraindications is essential during treatment. Overall, brodalumab represents a targeted therapeutic option in the management of autoimmune skin disorders.

<p>Brodalumab (AMG 827), a human IgG2 monoclonal antibody, inhibits IL-17R, treating psoriasis.</p>

<p>Anti-Human IL-17RA Monoclonal Antibody</p>

CAS 1174395-19-7

Brodalumab

Brodalumab

Ref: TM-T76779

Brodalumab

Ref: 3D-CLA1278