CAS 117592-45-7

α-Casozepine

CAS: 117592-45-7

α-Casozepine

Purity: ≥95%

Molecular weight: 1267.47g/mol

Ref: 54-BUP22118

α-Casozepine

CAS: 117592-45-7

α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.

Formula: C₆₀H₉₄N₁₄O₁₆

Color and Shape: Solid

Molecular weight: 1267.47

Ref: TM-T29892

α-Casozepine

CAS: 117592-45-7

Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site.  alpha-CZP binds with a significantly lower affinity than benzodiazepines.Intraperitoneal administration of Alpha-Casozepine (alpha-CZP) to rodents results in anticonvulsant and sleep-protecting effects. Human administration reduces physiological stress symptoms in stressed and control patients. alpha-CZP modulated neuronal activity in brain regions linked to anxiety regulation in mice.

Formula: C₆₀H₉₄N₁₄O₁₆

Molecular weight: 1,267.47 g/mol

Ref: 3D-CRB1001691

α-casozepine

CAS: 117592-45-7

CAS No. 117592-45-7 is an ion channel activator that belongs to the group of peptides. It is a high purity product with a purity of 99.5% and has been purified by HPLC. CAS No. 117592-45-7 activates voltage-gated sodium channels in neuronal tissue, which may be due to its ability to bind to the receptor site and activate it, or by binding to the protein and changing its conformation to allow ions through the channel pore. The specificity of this ligand has been shown using antibody inhibition assays on rat erythrocytes and human erythrocytes.

Formula: C₆₀H₉₄N₁₄O₁₆

Purity: Min. 95%

Molecular weight: 1,267.5 g/mol

Ref: 3D-SEA59245