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CAS 117665-48-2

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(ala8,13,18)-magainin ii amide

Description:
(Ala8,13,18)-magainin II amide is a synthetic derivative of magainin II, a peptide originally isolated from the skin of the African clawed frog, Xenopus laevis. This compound is characterized by its amphipathic nature, which allows it to interact with lipid membranes, making it a subject of interest in antimicrobial and therapeutic research. The presence of alanine residues at specific positions enhances its stability and bioactivity. As an amide, it features a functional group that contributes to its solubility and interaction with biological systems. The peptide exhibits antimicrobial properties, targeting a broad spectrum of bacteria and fungi, which is attributed to its ability to disrupt microbial membranes. Additionally, its structure may influence its efficacy and selectivity, making it a valuable candidate for developing new antimicrobial agents. Research into its mechanisms of action and potential applications in medicine continues to be an area of active investigation. Overall, (Ala8,13,18)-magainin II amide represents a promising avenue in peptide-based therapeutics.
Formula:C116H185N31O27S
InChI:InChI=1/C116H185N31O27S/c1-15-65(7)94(145-90(150)58-121)114(172)125-60-91(151)132-76(40-26-30-47-117)103(161)141-84(54-73-36-22-18-23-37-73)111(169)139-82(52-63(3)4)110(168)142-86(56-75-59-124-62-126-75)109(167)129-67(9)97(155)127-68(10)98(156)134-78(42-28-32-49-119)104(162)136-79(43-29-33-50-120)105(163)140-83(53-72-34-20-17-21-35-72)108(166)130-69(11)99(157)133-77(41-27-31-48-118)102(160)128-70(12)101(159)138-85(55-74-38-24-19-25-39-74)113(171)146-93(64(5)6)115(173)131-71(13)100(158)135-80(44-45-92(152)153)107(165)147-95(66(8)16-2)116(174)137-81(46-51-175-14)106(164)143-87(57-89(122)149)112(170)144-88(61-148)96(123)154/h17-25,34-39,59,62-71,76-88,93-95,148H,15-16,26-33,40-58,60-61,117-121H2,1-14H3,(H2,122,149)(H2,123,154)(H,124,126)(H,125,172)(H,127,155)(H,128,160)(H,129,167)(H,130,166)(H,131,173)(H,132,151)(H,133,157)(H,134,156)(H,135,158)(H,136,162)(H,137,174)(H,138,159)(H,139,169)(H,140,163)(H,141,161)(H,142,168)(H,143,164)(H,144,170)(H,145,150)(H,146,171)(H,147,165)(H,152,153)/t65?,66?,67-,68-,69-,70-,71-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,93-,94-,95-/m0/s1
SMILES:CCC(C)[C@@H](C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CC(C)C)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](C)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](C)C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](C(C)C)C(=N[C@@H](C)C(=N[C@@H](CCC(=O)O)C(=N[C@@H](C(C)CC)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=N)O)C(=N[C@@H](CO)C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(CN)O
Synonyms:
  • Magainin B
  • L-Serinamide, glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-histidyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-phenylalanyl-L-alanyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-methionyl-L-asparaginyl-
  • Magainin I, 8-L-alanine-10-L-lysine-13-L-alanine-18-L-alanine-22-L-asparagine-23-L-serinamide-
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