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CAS 117707-40-1

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Desmethyl Levofloxacin

Description:
Desmethyl Levofloxacin, with the CAS number 117707-40-1, is a derivative of the fluoroquinolone antibiotic levofloxacin. It is characterized by its structural modification, specifically the absence of a methyl group at the nitrogen atom in the piperazine ring, which distinguishes it from its parent compound. This alteration can influence its pharmacological properties, including its antibacterial activity and spectrum of action. Desmethyl Levofloxacin exhibits broad-spectrum antimicrobial activity, primarily against Gram-negative and some Gram-positive bacteria, making it useful in treating various infections. The compound is typically administered in a form that allows for effective absorption and distribution in the body. Its mechanism of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. Additionally, like other fluoroquinolones, it may have side effects and contraindications, necessitating careful consideration in clinical use. Overall, Desmethyl Levofloxacin represents an important compound in the study of antibiotic efficacy and resistance.
Formula:C17H18FN3O4
InChI:InChI=1/C17H18FN3O4/c1-9-8-25-16-13-10(15(22)11(17(23)24)7-21(9)13)6-12(18)14(16)20-4-2-19-3-5-20/h6-7,9,19H,2-5,8H2,1H3,(H,23,24)/t9-/m0/s1
SMILES:C[C@H]1COc2c3c(cc(c2N2CCNCC2)F)c(=O)c(cn13)C(=O)O
Synonyms:
  • (3S)-9-Fluoro-2,3-dihydro-3-methyl-7-oxo-10-(1-piperazinyl)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • Dn 5455
  • (3S)-9-fluoro-3-methyl-7-oxo-10-piperazin-1-yl-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
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