CAS 1177356-70-5

(+)-Blebbistatin

CAS: 1177356-70-5

(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective myosin II ATPase inhibitor.

Formula: C₁₈H₁₆N₂O₂

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 292.33

Ref: TM-T12503

(+)-Blebbistatin

CAS: 1177356-70-5

(+)-Blebbistatin

Purity: ≥95%

Molecular weight: 292.33g/mol

Ref: 54-BUP09824

(R)-(+)-Blebbistatin

Controlled Product

CAS: 1177356-70-5

Applications (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.
References (1) Straight, A.F., et al.: Science (2003) 299: 1743-7(2) Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun (2004) 313: 992-7 (3) Kovacs, M., et al.: J. Biol. Chem. (2004) 279: 35557-63

Formula: C₁₈H₁₆N₂O₂

Color and Shape: Neat

Molecular weight: 292.33

Ref: TR-B592495

(R)-(+)-Blebbistatin

CAS: 1177356-70-5

(R)-(+)-Blebbistatin is a ketone that inhibits the synthesis of fatty acids in bacteria, which are necessary for the production of cell membrane lipids. The compound also inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. (R)-(+)-Blebbistatin has been shown to be an efficient antimicrobial agent against drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus and Escherichia coli. The bactericidal effects of the drug have been attributed to its ability to inhibit fatty acid synthesis.

Formula: C₁₈H₁₆N₂O₂

Purity: Min. 95%

Molecular weight: 292.34 g/mol

Ref: 3D-CXB35670