CAS 118-42-3

Hydroxychloroquine

Description:

Hydroxychloroquine is a synthetic compound primarily used as an antimalarial and immunomodulatory agent. It belongs to the class of drugs known as 4-aminoquinolines and is characterized by its ability to inhibit the growth of certain parasites, particularly Plasmodium species, which cause malaria. The chemical structure of hydroxychloroquine includes a hydroxyl group, which enhances its solubility and bioavailability compared to its predecessor, chloroquine. It is also utilized in the treatment of autoimmune diseases such as rheumatoid arthritis and lupus erythematosus due to its immunosuppressive properties. Hydroxychloroquine functions by interfering with the communication of immune cells and modulating inflammatory responses. The substance is generally well-tolerated, but it can have side effects, including gastrointestinal disturbances and potential retinal toxicity with long-term use. Its mechanism of action involves the alteration of lysosomal pH, which affects antigen processing and presentation. Hydroxychloroquine has gained attention in recent years for its potential role in treating viral infections, although its efficacy in this context remains under investigation.

Formula: C₁₈H₂₆ClN₃O

InChI: InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)

InChI key: InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N

SMILES: N(C(CCCN(CCO)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Synonyms:

• (.+-.)-Hydroxychloroquine
• 2-([4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino)ethan-1-ol
• 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol
• 7-Chloro-4-[4'-[ethyl (2''-hydroxyethyl) amino]-1'-methylbutylamino]quinoline
• 7-Chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline
• 7-Chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
• Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-
• Hidroxicloroquina
• Hydroxychlorochin
• Oxichloroquine
• Oxychlorochin
• Oxychloroquine
• Racemic Hydroxychloroquine
• Win 1258
• Win 1258-2

Hydroxychloroquine Sulfate

CAS: 118-42-3, 747-36-4

Formula: C₁₈H₂₆ClN₃O·H₂SO₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 433.95

Ref: 3B-H1306

2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol sulfate

CAS: 118-42-3

Formula: C₁₈H₂₆ClN₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 335.8715

Ref: IN-DA00JGHK

Hydroxychloroquine

CAS: 118-42-3

Hydroxychloroquine

Purity: ≥98%

Molecular weight: 335.87g/mol

Ref: 54-BUP16081

Hydroxychloroquine

CAS: 118-42-3

Hydroxychloroquine

Purity: 99%

Molecular weight: 335.87g/mol

Ref: 54-OR1013545

Hydroxychloroquine

CAS: 118-42-3

HCQ, an anti-malarial, may induce cancer cell death and is being explored for COVID-19.

Formula: C₁₈H₂₆ClN₃O

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 335.87

Ref: TM-T9287

Hydroxychloroquine

Controlled Product

CAS: 118-42-3

Applications An antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product.
References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),

Formula: C₁₈H₂₆ClN₃O

Color and Shape: Neat

Molecular weight: 335.87

Ref: TR-B419750

HYDROXYCHLOROQUINE

CAS: 118-42-3

Purity: 97%

Molecular weight: 335.8800049

Ref: 10-F837323

Hydroxy Choroquine-D5 Phosphate Salt

Controlled Product

CAS: 118-42-3, 6168-85-0, 645406-23-1

Formula: C₁₈H₂₁D₅ClN₃O·2(H₃PO₄)

Color and Shape: Neat

Molecular weight: 536.88

Ref: TR-H905306