CAS 118122-39-7

bradykinin, Phe(8)-psi-CH2NH-Arg(9)-

Description:

Bradykinin, Phe(8)-psi-CH2NH-Arg(9)-, is a synthetic analog of the naturally occurring peptide bradykinin, which is known for its role in vasodilation and inflammation. This specific variant features a modification at the phenylalanine residue at position 8, where the peptide bond is replaced with a methylene bridge (psi-CH2NH), enhancing its stability against enzymatic degradation. The presence of the arginine residue at position 9 contributes to its biological activity, particularly in interacting with bradykinin receptors. This compound exhibits characteristics typical of peptide hormones, including solubility in water and a tendency to form secondary structures such as alpha-helices or beta-sheets in solution. Its pharmacological properties make it of interest in research related to cardiovascular health, pain modulation, and inflammatory responses. The CAS number 118122-39-7 uniquely identifies this compound, facilitating its recognition in scientific literature and databases. Overall, this modified bradykinin analog represents a valuable tool for studying peptide interactions and therapeutic applications.

Formula: C₅₀H₇₅N₁₅O₁₀

InChI: InChI=1/C50H75N15O10/c51-34(16-7-21-56-49(52)53)45(71)65-25-11-20-40(65)47(73)64-24-9-18-38(64)43(69)59-29-41(67)61-36(27-32-14-5-2-6-15-32)42(68)62-37(30-66)46(72)63-23-10-19-39(63)44(70)60-33(26-31-12-3-1-4-13-31)28-58-35(48(74)75)17-8-22-57-50(54)55/h1-6,12-15,33-40,58,66H,7-11,16-30,51H2,(H,59,69)(H,60,70)(H,61,67)(H,62,68)(H,74,75)(H4,52,53,56)(H4,54,55,57)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1

SMILES: c1ccc(cc1)C[C@@H](CN[C@@H](CCCNC(=N)N)C(=O)O)N=C([C@@H]1CCCN1C(=O)[C@H](CO)N=C([C@H](Cc1ccccc1)N=C(CN=C([C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O)O)O

Synonyms:

• 8-Phe-9-psi-CH2NH-arg-bradykinin
• Bradykinin, phenylalanyl(8)-psi-(methylamino)-arginine(9)-
• Ppcna-BK
• Bradykinin, 7-(N-(1-(((4-((aminoiminomethyl)amino)-1-carboxybutyl)amino)methyl)-2-phenylethyl)-L-prolinamide)-8-de-L-phenylalanine-9-de-L-arginine-, (S)-
• N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-N-[(1S)-1-benzyl-2-({(1S)-1-carboxy-4-[(diaminomethylidene)amino]butyl}amino)ethyl]-L-prolinamide
• Bradykinin, phe(8)-psi-CH2NH-arg(9)-

[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

CAS: 118122-39-7

Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage.

Formula: C₅₀H₇₅N₁₅O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 1046.23

Ref: TM-TP2076

[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

CAS: 118122-39-7

Bradykinin is a peptide hormone that is released by the cells in the walls of blood vessels in response to injury. Bradykinin causes contraction of smooth muscle and dilation of blood vessels, which results in an increase in blood pressure. Bradykinin also stimulates the release of stomach acid, which can lead to ulcers and bleeding. This product does not contain any impurities or contaminants and has been shown to be a potent activator for ion channels.

Formula: C₅₀H₇₅N₁₅O₁₀

Purity: Min. 95%

Molecular weight: 1,046.2 g/mol

Ref: 3D-TEA12239