CAS 118231-04-2

tachyplesin

Description:

Tachyplesin is a peptide derived from the blood of the horseshoe crab, specifically from the species Tachypleus tridentatus. It is known for its antimicrobial properties, exhibiting activity against a range of bacteria, fungi, and viruses. Tachyplesin is characterized by its relatively small size, typically consisting of around 18 amino acids, and features a unique structure that includes a high proportion of positively charged residues, which contribute to its ability to disrupt microbial membranes. The peptide is also notable for its stability and resistance to proteolytic degradation, making it a subject of interest in biomedical research, particularly in the development of new antimicrobial agents. Additionally, tachyplesin has been studied for its potential applications in wound healing and as a model for designing synthetic antimicrobial peptides. Its CAS number, 118231-04-2, is used for identification in chemical databases and regulatory contexts. Overall, tachyplesin represents a significant example of natural antimicrobial compounds with potential therapeutic applications.

Formula: C₉₉H₁₅₁N₃₅O₁₉S₄

InChI: InChI=1/C99H151N35O19S4/c1-5-53(4)78-94(153)132-75-51-157-156-50-74(91(150)127-69(43-55-28-32-58(135)33-29-55)85(144)121-64(24-14-38-114-96(105)106)81(140)119-47-76(137)133-78)131-93(152)77(52(2)3)134-84(143)67(27-17-41-117-99(111)112)124-86(145)68(42-54-18-7-6-8-19-54)126-90(149)73(130-88(147)71(125-80(139)61(101)21-11-12-36-100)45-57-46-118-62-22-10-9-20-60(57)62)49-155-154-48-72(89(148)120-63(79(102)138)23-13-37-113-95(103)104)129-83(142)66(26-16-40-116-98(109)110)122-82(141)65(25-15-39-115-97(107)108)123-87(146)70(128-92(75)151)44-56-30-34-59(136)35-31-56/h6-10,18-20,22,28-35,46,52-53,61,63-75,77-78,118,135-136H,5,11-17,21,23-27,36-45,47-51,100-101H2,1-4H3,(H2,102,138)(H,119,140)(H,120,148)(H,121,144)(H,122,141)(H,123,146)(H,124,145)(H,125,139)(H,126,149)(H,127,150)(H,128,151)(H,129,142)(H,130,147)(H,131,152)(H,132,153)(H,133,137)(H,134,143)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116)(H4,111,112,117)/t53-,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,77-,78-/m0/s1

SMILES: CC[C@H](C)[C@H]1C(=N[C@H]2CSSC[C@@H](C(=N[C@@H](Cc3ccc(cc3)O)C(=N[C@@H](CCCNC(=N)N)C(=NCC(=N1)O)O)O)O)N=C([C@H](C(C)C)N=C([C@H](CCCNC(=N)N)N=C([C@H](Cc1ccccc1)N=C([C@H](CSSC[C@@H](C(=N[C@@H](CCCNC(=N)N)C(=N)O)O)N=C([C@H](CCCNC(=N)N)N=C([C@H](CCCNC(=N)N)N=C([C@H](Cc1ccc(cc1)O)N=C2O)O)O)O)N=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](CCCCN)N)O)O)O)O)O)O)O

Synonyms:

• Tachyplesin I
• Tachyplesin
• L-Argininamide, L-lysyl-L-tryptophyl-L-cysteinyl-L-phenylalanyl-L-arginyl-L-valyl-L-cysteinyl-L-tyrosyl-L-arginylglycyl-L-isoleucyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-arginyl-L-cysteinyl-, cyclic (3→16),(7→12)-bis(disulfide)
• Tachyplesin I (9CI)
• Tachyplesin peptide, Tachypleus tridentatus

Tachyplesin I

CAS: 118231-04-2

Tachyplesin I is an antimicrobial peptide originally detected in the extract of hemocytes from the Japanese horseshoe crab. It inhibits the growth of both Gramnegative and -positive bacteria and forms a complex with bacterial lipopolysaccharides. These results suggest that this peptide belongs to the family of arthropodous peptide antibiotics. Furthermore this peptide has been shown to have antiviral activity against vesicular stomatitis virus, influenza A virus and HIV-1.

Formula: C₉₉H₁₅₁N₃₅O₁₉S₄

Purity: > 97%

Color and Shape: White Powder

Molecular weight: 2263.78

Ref: 01-4030734

Tachyplesin I trifluoroacetate

CAS: 118231-04-2

Tachyplesin I trifluoroacetate is an antimicrobial peptide with action on bacterial and fungal membranes by disrupting their integrity and is used for research on antimicrobial properties and potential therapeutic applications.

Formula: C₉₉H₁₅₁N₃₅O₁₉S₄•(C₂HF₃O₂)x

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 2,263.75 g/mol

Ref: 3D-FT108379