CAS 118267-18-8

N-DEMETHYLROXITHROMYCIN

Description:

N-Demethylroxithromycin is a semi-synthetic macrolide antibiotic derived from erythromycin. It is primarily used for its antibacterial properties, particularly against respiratory tract infections and certain skin infections. The compound exhibits a broad spectrum of activity against various Gram-positive and some Gram-negative bacteria, making it effective in treating infections caused by these pathogens. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the growth and reproduction of bacteria. N-Demethylroxithromycin is characterized by its stability in acidic environments, which enhances its bioavailability when administered orally. Additionally, it has a relatively long half-life, allowing for less frequent dosing compared to some other antibiotics. The substance is generally well-tolerated, though potential side effects may include gastrointestinal disturbances and allergic reactions. As with any antibiotic, appropriate use is crucial to minimize the risk of developing antibiotic resistance.

Formula: C₄₀H₇₄N₂O₁₅

Synonyms:

• RU 44981
• (E)-N-DeMethylroxithroMycin
• Roxithromycin Impurity 6(Roxithromycin EP Impurity F)
• Roxithromycin Impurity
• Roxithromycin Impurity R
• Roxithromycin Impurity F
• Roxithromycin EP Impurity F/(3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-4-(((2R,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-10-
• (9E)-9-[O-[(2-Methoxyethoxy)Methyl]oxiMe]-N-deMethyl ErythroMycin
• Erythromycin, N-demethyl-, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)-
• N-DEMETHYLROXITHROMYCIN

Roxithromycin EP Impurity F

CAS: 118267-18-8

Formula: C₄₀H₇₄N₂O₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 823.03

Ref: 4Z-R-748

N-Demethyl Roxithromycin

CAS: 118267-18-8

Applications A metabolite of Roxithromycin (R700850).
References Lindstrom, T., et al.: Antimicrob. Agents Chemother., 37, 265 (1993), Shimada, T., et al.: J. Pharmacol. Exp. Ther., 270, 414 (1994), Yamazaki, H., et al.: J. Toxicol. Sci., 21, 215 (1996),

Formula: C₄₀H₇₄N₂O₁₅

Color and Shape: White To Off-White

Molecular weight: 823.02

Ref: TR-D231265

Roxithromycin EP Impurity F

CAS: 118267-18-8

Formula: C₄₀H₇₄N₂O₁₅

Molecular weight: 823

Ref: ST-EA-CP-R20008

N-Demethyl roxithromycin

CAS: 118267-18-8

N-Demethyl roxithromycin is a metabolite of roxithromycin with action on bacterial protein synthesis inhibition and is used for research on macrolide antibiotics.

Formula: C₄₀H₇₄N₂O₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 823.02 g/mol

Ref: 3D-AD21014

N-Demethyl Roxithromycin-d7

Controlled Product

CAS: 118267-18-8

Formula: C₄₀H₆₇D₇N₂O₁₅

Color and Shape: Neat

Molecular weight: 152.111

Ref: TR-D231267