CAS 118288-08-7: Lafutidine

Description: Lafutidine is a synthetic compound primarily used as a medication for the treatment of gastrointestinal disorders, particularly for its role as an anti-ulcer agent. It belongs to the class of drugs known as histamine H2 receptor antagonists, which function by inhibiting the action of histamine on H2 receptors in the stomach lining, thereby reducing gastric acid secretion. This mechanism helps in alleviating conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). Lafutidine is characterized by its ability to promote mucosal defense mechanisms, enhancing the production of mucus and bicarbonate, which further protects the gastric lining. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other H2 antagonists. Its pharmacokinetics involve absorption in the gastrointestinal tract, with metabolism primarily occurring in the liver. Overall, Lafutidine represents a valuable therapeutic option in managing acid-related gastrointestinal conditions, contributing to both symptom relief and mucosal healing.

Formula: C₂₂H₂₉N₃O₄S

InChI: InChI=1/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-

InChI key: InChIKey=KMZQAVXSMUKBPD-DJWKRKHSNA-N

SMILES: O=C(NCC=CCOC1=NC=CC(=C1)CN2CCCCC2)CS(=O)CC=3OC=CC3

Synonyms:

• (+)-2-(Furfurylsulfinyl)-N-[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]acetamide
• (+)-2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide
• 2-[(furan-2-ylmethyl)sulfinyl]-N-[(2Z)-4-{[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}but-2-en-1-yl]acetamide
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]-, (+)-
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (+)-
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (Z)-(+)-
• Frg 8813
• Laflutidine
• Lafukem
• N-(4-(4-Piperidinylmethyl)Pyridyl-2-Oxy)Butenyl-2-(Furfurylsulfinyl)Acetamide
• Protecadin
• Stogar

Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (+)-

CAS: 118288-08-7

• Formula: C₂₂H₂₉N₃O₄S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 431.5484

Lafutidine

CAS: 118288-08-7

Lafutidine (FRG-8813) is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.

• Formula: C₂₂H₂₉N₃O₄S
• Purity: 99.94%
• Color and Shape: Yellowish White Crystalline Powder
• Molecular weight: 431.55

Lafutidine

CAS: 118288-08-7

• Formula: C₂₂H₂₉N₃O₄S
• Molecular weight: 431.55

Lafutidine

CAS: 118288-08-7

• Formula: C₂₂H₂₉N₃O₄S
• Color and Shape: Off-White Solid
• Molecular weight: 431.55

Lafutidine-d10

CAS: 118288-08-71795136-26-3

• Formula: C₂₂H₁₉D₁₀N₃O₄S
• Color and Shape: White To Off-White Solid
• Molecular weight: 441.61

Lafutidine

CAS: 118288-08-7

• Formula: C₂₂H₂₉N₃O₄S
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 431.55

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide

CAS: 118288-08-7

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 431.54998779296875

Lafutidine

CAS: 118288-08-7

Histamine (H2) receptor antagonist; treats ulcers and acid reflux

• Formula: C₂₂H₂₉N₃O₄S
• Purity: Min. 95%
• Molecular weight: 431.55 g/mol

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide

CAS: 118288-08-7

Applications (Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide is a Histaminic H2 receptor antagonists in ulcer disease. Also, it is a …

• Formula: C₂₂H₂₉N₃O₄S
• Color and Shape: Neat
• Molecular weight: 431.55