CAS 118288-08-7

Lafutidine

Description:

Lafutidine is a synthetic compound primarily used as a medication for the treatment of gastrointestinal disorders, particularly for its role as an anti-ulcer agent. It belongs to the class of drugs known as histamine H2 receptor antagonists, which function by inhibiting the action of histamine on H2 receptors in the stomach lining, thereby reducing gastric acid secretion. This mechanism helps in alleviating conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). Lafutidine is characterized by its ability to promote mucosal defense mechanisms, enhancing the production of mucus and bicarbonate, which further protects the gastric lining. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other H2 antagonists. Its pharmacokinetics involve absorption in the gastrointestinal tract, with metabolism primarily occurring in the liver. Overall, Lafutidine represents a valuable therapeutic option in managing acid-related gastrointestinal conditions, contributing to both symptom relief and mucosal healing.

Formula: C₂₂H₂₉N₃O₄S

InChI: InChI=1/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2-

InChI key: InChIKey=KMZQAVXSMUKBPD-DJWKRKHSNA-N

SMILES: C(C=1C=C(OC/C=C\CNC(CS(CC2=CC=CO2)=O)=O)N=CC1)N3CCCCC3

Synonyms:

• (+)-2-(Furfurylsulfinyl)-N-[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]acetamide
• (+)-2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide
• 2-[(furan-2-ylmethyl)sulfinyl]-N-[(2Z)-4-{[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxy}but-2-en-1-yl]acetamide
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]-, (+)-
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (+)-
• Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (Z)-(+)-
• Frg 8813
• Laflutidine
• Lafukem
• N-(4-(4-Piperidinylmethyl)Pyridyl-2-Oxy)Butenyl-2-(Furfurylsulfinyl)Acetamide
• Protecadin

Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-, (+)-

CAS: 118288-08-7

Formula: C₂₂H₂₉N₃O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 431.5484

Ref: IN-DA00HEG4

Lafutidine

CAS: 118288-08-7

Lafutidine (FRG-8813) is a newly developed histamine H(2)-receptor antagonist, which can inhibit gastric acid secretion.

Formula: C₂₂H₂₉N₃O₄S

Purity: 98.55%

Color and Shape: Yellowish White Crystalline Powder

Molecular weight: 431.55

Ref: TM-T0081

Lafutidine

CAS: 118288-08-7

Formula: C₂₂H₂₉N₃O₄S

Color and Shape: Off-White Solid

Molecular weight: 431.55

Ref: 4Z-L-471

Lafutidine

CAS: 118288-08-7

Lafutidine

Purity: 99%

Molecular weight: 431.55g/mol

Ref: 54-OR1028229

Lafutidine

CAS: 118288-08-7

Formula: C₂₂H₂₉N₃O₄S

Molecular weight: 431.55

Ref: 7W-GP1914

Lafutidine

CAS: 118288-08-7

Lafutidine

Purity: ≥98%

Molecular weight: 431.55g/mol

Ref: 54-BUP11714

Lafutidine-d10

CAS: 118288-08-7, 1795136-26-3

Formula: C₂₂H₁₉D₁₀N₃O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 441.61

Ref: 4Z-L-476

Lafutidine

CAS: 118288-08-7

Formula: C₂₂H₂₉N₃O₄S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 431.55

Ref: 3B-L0341

Lafutidine

CAS: 118288-08-7

Histamine (H2) receptor antagonist; treats ulcers and acid reflux

Formula: C₂₂H₂₉N₃O₄S

Purity: Min. 95%

Molecular weight: 431.55 g/mol

Ref: 3D-FP145753

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-N-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide

CAS: 118288-08-7

Formula: C₂₂H₂₉N₃O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 431.55

Ref: 10-F079405

(Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide

Controlled Product

CAS: 118288-08-7

Applications (Z)-2-((Furan-2-ylmethyl)sulfinyl)-n-(4-((3-(piperidin-1-ylmethyl)pyridin-2-yl)oxy)but-2-en-1-yl)acetamide is a Histaminic H2 receptor antagonists in ulcer disease. Also, it is a model compound used to investigate the binding mechanism between antiulcer drugs and human serum albumin (HSA).
References Patel, P. B., et al.: World J. Pharm. Sci., 5, 532-540 (2016); Yang, h., et al.: Arch. Biochem. Biophys., 606, 81-89 (2016);

Formula: C₂₂H₂₉N₃O₄S

Color and Shape: Neat

Molecular weight: 431.55

Ref: TR-F864058