CAS 118395-73-6

Chloroeremomycin

Description:

Chloroeremomycin is a chemical compound classified as a macrolide antibiotic, derived from the fermentation of certain actinomycetes. It is known for its antibacterial properties, particularly against Gram-positive bacteria. The structure of chloroeremomycin features a large lactone ring, which is characteristic of macrolides, and it contains chlorine substituents that contribute to its biological activity. This compound exhibits a mechanism of action similar to other macrolides, primarily by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. Chloroeremomycin has been studied for its potential therapeutic applications, especially in treating infections caused by resistant bacterial strains. Its pharmacological profile includes considerations of solubility, stability, and bioavailability, which are crucial for its effectiveness as an antibiotic. Additionally, like many antibiotics, it may have side effects and resistance patterns that are important for clinical use. Overall, chloroeremomycin represents a significant compound in the field of medicinal chemistry and antibiotic development.

Formula: C₇₃H₈₈Cl₂N₁₀O₂₆

InChI: InChI=1S/C73H88Cl2N10O26/c1-26(2)14-38(79-7)64(96)84-54-56(91)30-9-12-42(36(74)16-30)106-44-18-32-19-45(60(44)111-71-61(58(93)57(92)46(25-86)108-71)110-49-24-73(6,78)63(95)28(4)105-49)107-43-13-10-31(17-37(43)75)59(109-48-23-72(5,77)62(94)27(3)104-48)55-69(101)83-53(70(102)103)35-20-33(87)21-41(89)50(35)34-15-29(8-11-40(34)88)51(66(98)85-55)82-67(99)52(32)81-65(97)39(22-47(76)90)80-68(54)100/h8-13,15-21,26-28,38-39,46,48-49,51-59,61-63,71,79,86-89,91-95H,14,22-25,77-78H2,1-7H3,(H2,76,90)(H,80,100)(H,81,97)(H,82,99)(H,83,101)(H,84,96)(H,85,98)(H,102,103)/t27-,28-,38+,39-,46+,48-,49-,51+,52+,53-,54+,55-,56+,57+,58-,59+,61+,62-,63-,71-,72-,73-/m0/s1

InChI key: InChIKey=XJHXLMVKYIVZTE-LOALFDMRSA-N

SMILES: O(C=1C2=CC3=CC1OC=4C(Cl)=CC(=CC4)[C@@H](O)[C@@H](NC([C@@H](CC(C)C)NC)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@]3(C(=O)N[C@@]5(C=6C=C(C=7C([C@@H](C(O)=O)NC(=O)[C@]([C@H](O[C@H]8C[C@](C)(N)[C@@H](O)[C@H](C)O8)C=9C=C(Cl)C(O2)=CC9)(NC5=O)[H])=CC(O)=CC7O)C(O)=CC6)[H])[H])[C@H]%10[C@H](O[C@H]%11C[C@](C)(N)[C@@H](O)[C@H](C)O%11)[C@@H](O)[C@H](O)[C@@H](CO)O%10

Synonyms:

• (1S,2R,18R,19R,22S,25R,28R,40R)-2-{[(2R,4S,5R,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-48-{[(2S,3R,5S,6R)-3-{[(2S,4S,5R,6S)-4-amino-5-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-18,32,35,37-tetrahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2~3,6~.2~14,17~.1~8,12~.1~29,33~.0~10,25~.0~34,39~]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid (non-preferred name)
• (4′′R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)vancomycin
• 22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine, vancomycin deriv.
• 8-82846A
• A 82846B
• A83846B
• Antibiotic A 82846B
• Antibiotic PA 45052A
• Chloroeremomycin
• Ly 264826
• Pa 45052A
• Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-, (4''R)-
• Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl)-, (4′′R)-
• (4′′R)-22-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)vancomycin
• A82846
• Chloroorienticin A

Chloroorienticin A

CAS: 118395-73-6

Chloroorienticin A is an antibiotic in the class of glycopeptide.

Formula: C₇₃H₈₈Cl₂N₁₀O₂₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 1592.45

Ref: TM-T27008

Chloroorienticin A

CAS: 118395-73-6

Formula: C₇₃H₈₈Cl₂N₁₀O₂₆

Molecular weight: 1592.45

Ref: 4Z-O-093001

Chloroeremomycin

CAS: 118395-73-6

Fementation intermediate of Oritavancin

Formula: C₇₃H₈₈Cl₂N₁₀O₂₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,592.44 g/mol

Ref: 3D-AC167119

Chloroorienticin A

CAS: 118395-73-6

Formula: C₇₃H₈₈Cl₂N₁₀O₂₆

Molecular weight: 1592.45

Ref: ST-EA-CP-O23007