CAS 118399-22-7: Nodularin, Nodularia spumigena

Description: Nodularin is a potent cyclic peptide toxin produced by the cyanobacterium Nodularia spumigena, commonly found in brackish and freshwater environments. It is primarily known for its hepatotoxic effects, which can lead to liver damage in humans and animals upon exposure. Nodularin is structurally similar to microcystins, another group of cyanobacterial toxins, and functions as an inhibitor of protein phosphatases, particularly protein phosphatase 1 and 2A, disrupting cellular signaling pathways. This disruption can result in various toxicological effects, including cell death and tumor promotion. Nodularin is typically found in aquatic ecosystems during algal blooms, which can be triggered by nutrient enrichment, particularly nitrogen and phosphorus. Its presence in water bodies poses significant risks to aquatic life and human health, especially through contaminated drinking water or seafood. Monitoring and management of cyanobacterial blooms are essential to mitigate the risks associated with nodularin and other cyanotoxins.

Formula: C₄₁H₆₀N₈O₁₀

InChI: InChI=1/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8+

Synonyms:

• Nodularin
• Hsdb 7749
• Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
• Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
• (2E)-9-{3-[(diaminomethylidene)amino]propyl}-2-ethylidene-12-[(1E,3E)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid

Nodularin

CAS: 118399-22-7

• Molecular weight: 824.96g/mol

Nodularin

CAS: 118399-22-7

Nodularin from N. spumigena is a hepatotoxic pentapeptide that inhibits PP1 and PP2A with IC50s …

• Formula: C₄₁H₆₀N₈O₁₀
• Color and Shape: Liquid
• Molecular weight: 824.977

Nodularin

CAS: 118399-22-7

• Formula: C₄₁H₆₀N₈O₁₀
• Molecular weight: 824.98

Nodularin

CAS: 118399-22-7

Nodularin is an indolic alkaloid that has been identified as a potent inhibitor of the …

• Formula: C₄₁H₆₀N₈O₁₀
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 824.96 g/mol