CAS 118409-57-7

tyrphostin 23

Description:

Tyrphostin 23, with the CAS number 118409-57-7, is a synthetic compound known for its role as a selective inhibitor of receptor tyrosine kinases, particularly the epidermal growth factor receptor (EGFR). This compound is part of a broader class of tyrphostins, which are characterized by their ability to interfere with signal transduction pathways involved in cell growth and differentiation. Tyrphostin 23 has been studied for its potential therapeutic applications in cancer treatment, as it can inhibit tumor cell proliferation and induce apoptosis in certain cancer cell lines. The compound typically exhibits moderate solubility in organic solvents and is often used in biochemical research to elucidate the mechanisms of receptor signaling. Its structure includes specific functional groups that contribute to its inhibitory activity, making it a valuable tool in pharmacological studies. As with many chemical substances, handling and usage should adhere to safety protocols to mitigate any potential hazards associated with its biological activity.

Formula: C₁₀H₆N₂O₂

InChI: InChI=1/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChI key: InChIKey=VTJXFTPMFYAJJU-UHFFFAOYSA-N

SMILES: C(=C(C#N)C#N)C1=CC(O)=C(O)C=C1

Synonyms:

• (3,4-Dihydroxybenzylidene)malononitrile
• 2-(3,4-Dihydroxybenzylidene)malononitrile
• 2-[(3,4-Dihydroxyphenyl)methylene]propanedinitrile
• 2-[(3,4-Dihydroxyphenyl)methylidene]propanedinitrile
• AG 18 (pharmaceutical)
• Ag 18
• Propanedinitrile, 2-[(3,4-dihydroxyphenyl)methylene]-
• Propanedinitrile, [(3,4-dihydroxyphenyl)methylene]-
• Rg 50810
• Rg 50858
• Tx 825
• Tyrphostin A 23
• Tyrphostin AG 18
• AG 18 (Tyrphostin 23)
• Tyrphostin AG 1
• AG18, >=98%
• (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810
• TYRPHOSTIN A23
• AG 18 (Tyrphostin A23)
• (3,4-Dihydroxyphenyl)methylene propanedinitrile
• AG 18 (3,4-Dihydroxybenzylidene)malononitrile 2-(3,4-Dihydroxybenzylidene)malononitrile
• [(3,4-DIHYDROXYPHENYL)METHYLENE]-PROPENEDINITRILE
• ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE
• 2-(3,4-Dihydroxyphenyl)ethene-1,1-dicarbonitrile
• TYRPHOSTIN RG 50858
• TYRPHOSTIN 23
• α-Cyano-(3,4-dihydroxy)cinnamonitrile&nbsp
• RARECHEM AL BX 0069
• 4,5-Dihydroxybenzylidenemalononitrile
• AG-18(RG-50810)
• TYRPHOSTIN A23 99+%

Tyrphostin A23

CAS: 118409-57-7

Formula: C₁₀H₆N₂O₂

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 186.17

Ref: 3B-T3503

Tyrphostin A23, 99%

CAS: 118409-57-7

Potent inhibitor of EGF receptor kinase activity

Formula: C₁₀H₆N₂O₂

Purity: 99%

Molecular weight: 186.17

Ref: 02-J60308

Tyrphostin 23

CAS: 118409-57-7

Tyrphostin 23

Purity: ≥98%

Molecular weight: 186.17g/mol

Ref: 54-BUP06871

2-(3,4-Dihydroxybenzylidene)Malononitrile

CAS: 118409-57-7

2-(3,4-Dihydroxybenzylidene)Malononitrile

Purity: 98%

Molecular weight: 186.17g/mol

Ref: 54-OR1009711

Tyrphostin 23

CAS: 118409-57-7

Formula: C₁₀H₆N₂O₂

Purity: (GC) ≥ 98.0%

Color and Shape: White to light yellow crystalline powder

Molecular weight: 186.17

Ref: 7W-GK2254

Tyrphostin 23

CAS: 118409-57-7

Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.

Formula: C₁₀H₆N₂O₂

Purity: 99.7% - 99.86%

Color and Shape: Yellow-Tan Solid

Molecular weight: 186.17

Ref: TM-T2063

Tyrphostin 23

Controlled Product

CAS: 118409-57-7

Stability Store in refrigerator
Applications A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
References Lyall, R. M., et al.: J. Biol. Chem., 264, 14503 (1989), Bryckaert, M.C., et al.: Exp. Cell Res., 199, 255 (1992)

Formula: C₁₀H₆N₂O₂

Color and Shape: Neat

Molecular weight: 186.17

Ref: TR-T923000

2-(3,4-Dihydroxybenzylidene)malononitrile

CAS: 118409-57-7

Purity: ≥98%

Molecular weight: 186.1699982

Ref: 10-F868712

Tyrphostin 23

CAS: 118409-57-7

Tyrphostin 23 is a chemical inhibitor of protein kinase C (PKC) and PKC-related kinases. It is used to study the role of PKC in cell signaling, as well as its function in various diseases, such as bowel disease. Tyrphostin 23 has been shown to be an activator of basic fibroblast growth factor (bFGF), which may be due to its ability to increase cytosolic calcium levels. It also has been shown to inhibit the polymerase chain reaction (PCR) in a number of cancer cells. Tyrphostin 23 binds to a protein target that is involved in apoptosis pathway and ATP channel activity, inhibiting the ion channels responsible for the flow of cations across the plasma membrane.

Formula: C₁₀H₆N₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 186.17 g/mol

Ref: 3D-FT28633