CAS 118414-82-7: MK-886

Description: MK-886, with the CAS number 118414-82-7, is a synthetic compound that functions primarily as a selective inhibitor of the enzyme 5-lipoxygenase (5-LO). This enzyme plays a crucial role in the biosynthesis of leukotrienes, which are inflammatory mediators involved in various pathological conditions, including asthma and other inflammatory diseases. MK-886 is characterized by its ability to modulate inflammatory responses, making it a subject of interest in pharmacological research. The compound is typically studied for its potential therapeutic applications in treating conditions associated with excessive leukotriene production. In terms of its chemical structure, MK-886 features a distinct arrangement of functional groups that contribute to its biological activity. It is important to note that while MK-886 has shown promise in preclinical studies, further research is necessary to fully understand its efficacy, safety profile, and potential clinical applications. As with many investigational compounds, its use is primarily confined to research settings until more definitive clinical data is available.

Formula: C₂₇H₃₄ClNO₂S

InChI: InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)

InChI key: InChIKey=QAOAOVKBIIKRNL-UHFFFAOYSA-N

SMILES: O=C(O)C(C)(C)CC1=C(SC(C)(C)C)C=2C=C(C=CC2N1CC3=CC=C(Cl)C=C3)C(C)C

Synonyms:

• 1-((4-Chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
• 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
• 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid
• 3-[3-(butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• L 663536

1H-Indole-2-propanoic acid,1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-

CAS: 118414-82-7

• Formula: C₂₇H₃₄ClNO₂S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 472.0824

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

CAS: 118414-82-7

• Purity: 98%
• Molecular weight: 472.08g/mol

MK-886

CAS: 118414-82-7

• Purity: 99.78%
• Molecular weight: 472.08g/mol

MK-886

CAS: 118414-82-7

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

• Formula: C₂₇H₃₄ClNO₂S
• Purity: 98.9% - 99.78%
• Color and Shape: Solid
• Molecular weight: 472.08

MK-886

CAS: 118414-82-7

Please enquire for more information about MK-886 including the price, delivery time and more detailed …

• Formula: C₂₇H₃₄ClNO₂S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 472.08 g/mol

MK 886 - Bio-X ™

CAS: 118414-82-7

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. …

• Formula: C₂₇H₃₄ClNO₂S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 472.08 g/mol

MK-886

CAS: 118414-82-7

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1. References Gillard, J., …

• Formula: C₂₇H₃₄ClNO₂S
• Color and Shape: Neat
• Molecular weight: 472.08