CAS 118414-82-7

MK-886

Description:

MK-886, with the CAS number 118414-82-7, is a synthetic compound that functions primarily as a selective inhibitor of the enzyme 5-lipoxygenase (5-LO). This enzyme plays a crucial role in the biosynthesis of leukotrienes, which are inflammatory mediators involved in various pathological conditions, including asthma and other inflammatory diseases. MK-886 is characterized by its ability to modulate inflammatory responses, making it a subject of interest in pharmacological research. The compound is typically studied for its potential therapeutic applications in treating conditions associated with excessive leukotriene production. In terms of its chemical structure, MK-886 features a distinct arrangement of functional groups that contribute to its biological activity. It is important to note that while MK-886 has shown promise in preclinical studies, further research is necessary to fully understand its efficacy, safety profile, and potential clinical applications. As with many investigational compounds, its use is primarily confined to research settings until more definitive clinical data is available.

Formula: C₂₇H₃₃ClNO₂S·Na

InChI: InChI=1/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31)

InChI key: InChIKey=QAOAOVKBIIKRNL-UHFFFAOYSA-N

SMILES: C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(C(C)C)=CC2)C3=CC=C(Cl)C=C3

Synonyms:

• 1-((4-Chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
• 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
• 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid
• 3-[3-(butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• L 663536
• MK 886
• MK 886
• CGS-81585
• 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
• 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt
• MK866
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
• MK-886 (L-663,536)
• MK-886 (Free Base)

1H-Indole-2-propanoic acid,1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-

CAS: 118414-82-7

Formula: C₂₇H₃₄ClNO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 472.0824

Ref: IN-DA008RN6

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

CAS: 118414-82-7

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

Purity: 98%

Molecular weight: 472.08g/mol

Ref: 54-OR1026587

MK-886

CAS: 118414-82-7

MK-886

Purity: ≥98%

Molecular weight: 472.08g/mol

Ref: 54-BUP07765

MK-886

CAS: 118414-82-7

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

Formula: C₂₇H₃₄ClNO₂S

Purity: 99.23% - 99.84%

Color and Shape: Solid

Molecular weight: 472.08

Ref: TM-T6893

MK-886

CAS: 118414-82-7

MK-886 is a synthetic compound, formally classified as a leukotriene biosynthesis inhibitor, which is derived through chemical synthesis processes. This compound acts by specifically targeting the 5-lipoxygenase-activating protein (FLAP), a crucial component in the leukotriene synthesis pathway. By inhibiting FLAP, MK-886 effectively suppresses the production of leukotrienes, which are lipid compounds that play a pivotal role in the inflammatory response.

Formula: C₂₇H₃₄ClNO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 472.08 g/mol

Ref: 3D-TEA41482

MK 886 - Bio-X ™

CAS: 118414-82-7

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.

Formula: C₂₇H₃₄ClNO₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 472.08 g/mol

Ref: 3D-BM166037

MK-886

Controlled Product

CAS: 118414-82-7

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

Formula: C₂₇H₃₄ClNO₂S

Color and Shape: Neat

Molecular weight: 472.08

Ref: TR-M425053