CAS 1184173-73-6

Formula: C37H41N9O3S

InChI: InChI=1S/C37H41N9O3S/c1-24(2)49-32-12-9-28(20-38-32)34-30-19-29(10-11-31(30)41-42-34)40-36(48)37(50-4)15-18-45(22-37)21-33(47)46-16-13-26(14-17-46)25-5-7-27(8-6-25)35-39-23-44(3)43-35/h5-13,19-20,23-24H,14-18,21-22H2,1-4H3,(H,40,48)(H,41,42)/t37-/m0/s1

InChI key: KPQQGHGDBBJGFA-QNGWXLTQSA-N

SMILES: CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)[C@@]4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC

MK-8353

CAS: 1184173-73-6

Formula: C₃₇H₄₁N₉O₃S

Purity: 99%

Color and Shape: Solid

Molecular weight: 691.8449

Ref: IN-DA01FVJ9

MK-8353

CAS: 1184173-73-6

MK-8353

Formula: C₃₇H₄₁N₉O₃S

Purity: ≥95%

Molecular weight: 691.84

Ref: 54-BUP14183

MK-8353

CAS: 1184173-73-6

(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide

Formula: C₃₇H₄₁N₉O₃S

Purity: 99%

Molecular weight: 691.85

Ref: IN-DG00803073

MK-8353 (SCH900353)

CAS: 1184173-73-6

MK-8353 is a novel, potent and selective inhibitor of the mek1/2 enzyme. It is active in vitro against a variety of human cancer cell lines, including metastatic colorectal cancer cells that are resistant to other tyrosine kinase inhibitors. MK-8353 has been found to inhibit tumor growth in vivo by inhibiting the phosphorylation of mek1/2 and its downstream signaling pathways. The compound also inhibited mutant melanoma growth in vivo and suppressed the proliferation of cervical cancer cells in vitro. MK-8353 is currently being evaluated for use as a potential anticancer drug candidate.

Formula: C₃₇H₄₁N₉O₃S

Purity: Min. 95%

Molecular weight: 691.84 g/mol

Ref: 3D-JXB17373

MK-8353

CAS: 1184173-73-6

MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)

Formula: C₃₇H₄₁N₉O₃S

Purity: 96.15% - 97.19%

Color and Shape: Orange Solid

Molecular weight: 691.845

Ref: TM-T12069