CAS 1184391-57-8

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide

Description:

2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide is a chemical compound characterized by its complex structure, which includes a pyridine ring, a hydrazine moiety, and a thioamide functional group. This compound typically exhibits properties associated with both hydrazines and thioamides, such as potential reactivity towards electrophiles and nucleophiles. The presence of the amino group on the pyridine ring can enhance its solubility in polar solvents and may influence its biological activity. The dimethyl substitution on the hydrazine nitrogen atoms can affect the compound's steric and electronic properties, potentially impacting its reactivity and interaction with biological targets. Additionally, compounds of this nature may exhibit interesting pharmacological properties, making them of interest in medicinal chemistry. However, specific characteristics such as melting point, boiling point, and solubility would require empirical data for precise values. Overall, this compound represents a unique structure that may have applications in various fields, including pharmaceuticals and agrochemicals.

Formula: C₉H₁₃N₅S

Synonyms:

• 3-AP-Me
• 2-[(3-Amino-2-pyridinyl)methylene]-N,N-dimethyl-hydrazinecarbothioamide
• Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-N,N-dimethyl-

3-Ap-Me

CAS: 1184391-57-8

3-Ap-Me is a pro-apoptotic peptide that inhibits protein synthesis and mitochondrial cytochrome c release. It has been shown to induce apoptosis in prostate cancer cells by inhibiting the synthesis of proteins necessary for cell division, such as Grp78. 3-Ap-Me also induces reactive oxygen species (ROS) production and mitochondrial membrane potential collapse, which leads to the activation of caspase-independent cell death in prostate cancer cells. 3-Ap-Me can be used to inhibit protein synthesis in cancer cells and may be a potential treatment for prostate cancer.

Formula: C₉H₁₃N₅S

Purity: Min. 95%

Molecular weight: 223.3 g/mol

Ref: 3D-JXB39157

3-AP-Me

CAS: 1184391-57-8

3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.

Formula: C₉H₁₃N₅S

Color and Shape: Solid

Molecular weight: 223.298

Ref: TM-T204216