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CAS 118457-15-1

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(+)-Nebivolol

Description:
(+)-Nebivolol is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure with minimal impact on heart rate, making it a preferred choice for patients with cardiovascular conditions. The compound exhibits a unique mechanism of action, as it not only blocks beta-1 receptors but also promotes vasodilation through the release of nitric oxide, contributing to its antihypertensive effects. Chemically, it is a chiral molecule, meaning it exists in two enantiomeric forms, with the (+) enantiomer being the active form responsible for its therapeutic effects. Its solubility profile indicates that it is moderately soluble in water, which influences its bioavailability. Additionally, (+)-Nebivolol has a favorable pharmacokinetic profile, with a relatively long half-life, allowing for once-daily dosing. Side effects are generally mild and may include fatigue, headache, and dizziness, making it well-tolerated among patients. Overall, (+)-Nebivolol represents a significant advancement in the management of cardiovascular diseases.
Formula:C22H25F2NO4
InChI:InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/m1/s1
Synonyms:
  • d-Nebivolol
  • R-67138
  • (aR,a’R,2R,2’S)-a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
  • (aR,a,2R,2)-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
  • (1R)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-({(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl}amino)ethanol
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