CAS 118476-85-0

(D-arg2,lys4) dermorphin fragment*1-4 amide

Description:

(D-Arg2,Lys4) dermorphin fragment 1-4 amide is a synthetic peptide derived from dermorphin, a naturally occurring opioid peptide found in the skin of certain frogs. This compound is characterized by its specific amino acid sequence, which includes D-arginine at position 2 and lysine at position 4, contributing to its biological activity. It exhibits high affinity for mu-opioid receptors, which are involved in pain modulation and analgesia. The amide form enhances its stability and bioavailability compared to its free acid counterpart. This peptide is of interest in pharmacological research due to its potential therapeutic applications in pain management and its role in studying opioid receptor interactions. Additionally, its structural features may influence its pharmacokinetics and pharmacodynamics, making it a valuable subject for further investigation in the development of novel analgesics. As with many peptides, its synthesis and characterization require careful consideration of purity and activity to ensure reliable results in biological assays.

Formula: C₃₀H₄₅N₉O₅

InChI: InChI=1/C30H45N9O5/c31-15-5-4-9-23(26(33)41)37-29(44)25(18-19-7-2-1-3-8-19)39-28(43)24(10-6-16-36-30(34)35)38-27(42)22(32)17-20-11-13-21(40)14-12-20/h1-3,7-8,11-14,22-25,40H,4-6,9-10,15-18,31-32H2,(H2,33,41)(H,37,44)(H,38,42)(H,39,43)(H4,34,35,36)

SMILES: c1ccc(cc1)CC(C(=NC(CCCCN)C(=N)O)O)N=C(C(CCCNC(=N)N)N=C(C(Cc1ccc(cc1)O)N)O)O

Synonyms:

• Tyrosyl-arginyl-phenylalanyl-lysinamide
• Dalda
• Tyr-arg-phe-lys-NH2
• L-Lysinamide, L-tyrosyl-D-arginyl-L-phenylalanyl-
• L-tyrosyl-N~5~-(diaminomethylidene)-D-ornithyl-L-phenylalanyl-L-lysinamide

(D-Arg2,Lys4)-Dermorphin (1-4) Amide H-Tyr-D-Arg-Phe-Lys-NH2 Tristrifluoroacetate Salt

Controlled Product

CAS: 118476-85-0

Formula: C₃₀H₄₅N₉O₅•3(C₂HF₃O₂)

Color and Shape: White To Off-White

Molecular weight: 953.8

Ref: TR-D017168

(D-Arg2,Lys4)-Dermorphin (1-4) amide

CAS: 118476-85-0

Dermorphin is a neuropeptide that has been shown to reduce cortisol levels in badgers and has been shown to have biological activity in vitro. Dermorphin also has a number of pharmacokinetic properties, including water solubility, lipid solubility, and oral bioavailability. The drug binds to δ receptors and inhibits the enzyme activities of rat liver microsomes. Dermorphin is used as an analgesic for bowel disease, such as inflammatory bowel disease or hypogaea. Dermorphin has antinociceptive properties (pain-relieving).

Formula: C₃₀H₄₅N₉O₅

Purity: Min. 95%

Molecular weight: 611.74 g/mol

Ref: 3D-FA110358