The chemical substance known as "(phe4)-dermorphin fragment 1-4 amide," with the CAS number 118476-87-2, is a synthetic peptide derived from dermorphin, a naturally occurring opioid peptide found in the skin of certain frogs. This compound consists of a sequence of amino acids that typically exhibits high affinity for opioid receptors, particularly the mu-opioid receptor, which is associated with pain modulation and analgesic effects. The modification of the phenylalanine residue (indicated by "phe4") enhances its potency and selectivity. As a peptide, it is characterized by its relatively low molecular weight, solubility in polar solvents, and susceptibility to enzymatic degradation. Its potential applications include research in pain management, neurobiology, and the development of novel analgesics. However, due to its opioid nature, it also raises concerns regarding addiction and side effects, necessitating careful consideration in therapeutic contexts. Overall, this compound exemplifies the intersection of natural product chemistry and pharmacology, highlighting the importance of peptide modifications in drug design.

(phe4)-dermorphin fragment 1-4 amide

118476-87-2: The chemical substance known as "(phe4)-dermorphin fragment 1-4 amide," with the CAS number 118476-87-2, is a synthetic peptide derived from dermorphin, a naturally occurring opioid peptide found in the skin of certain frogs. This compound consists of a sequence of amino acids that typically exhibits high affinity for opioid receptors, particularly the mu-opioid receptor, which is associated with pain modulation and analgesic effects. The modification of the phenylalanine residue (indicated by "phe4") enhances its potency and selectivity. As a peptide, it is characterized by its relatively low molecular weight, solubility in polar solvents, and susceptibility to enzymatic degradation. Its potential applications include research in pain management, neurobiology, and the development of novel analgesics. However, due to its opioid nature, it also raises concerns regarding addiction and side effects, necessitating careful consideration in therapeutic contexts. Overall, this compound exemplifies the intersection of natural product chemistry and pharmacology, highlighting the importance of peptide modifications in drug design.

<p>Dermorphin is a peptide that is derived from the proenkephalin gene. It is an opioid analgesic and has been shown to be effective in the treatment of hernias. Dermorphin has also been shown to inhibit platelet aggregation and blood coagulation, making it an antithrombotic therapy. The structure of dermorphin has been determined using a hydroxy group as the reactive site for synthesis and molecular modelling techniques. Dermorphin has also been shown to have an active oxygen species selectivity index (a measure of antioxidant activity) higher than those of other drugs in its class, which makes it suitable for use as a sealant in abdominal surgery.</p>

CAS 118476-87-2

(phe4)-dermorphin fragment 1-4 amide

(Phe4)-Dermorphin (1-4) amide

Ref: 3D-FP110359