CAS 1185246-14-3

Amlodipine-d4

Description:

Amlodipine-d4 is a deuterated form of amlodipine, a calcium channel blocker primarily used in the treatment of hypertension and angina. The "d4" designation indicates that four hydrogen atoms in the amlodipine molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving drug metabolism and pharmacodynamics. Amlodipine-d4 retains the core structure and pharmacological activity of amlodipine, which works by inhibiting calcium ions from entering vascular smooth muscle and cardiac muscle, leading to vasodilation and reduced blood pressure. The compound is typically characterized by its molecular formula, molecular weight, and specific spectroscopic properties, such as NMR and mass spectrometry, which can help confirm its identity and purity. As a research chemical, it is important to handle amlodipine-d4 with care, following appropriate safety protocols.

Formula: C₂₀H₂₅ClN₂O₅

Synonyms:

• [2H4]-Amlodipine
• d-AMlodipine-d4
• PelMec-d4
• [2H4]-Amlodipine, racemic mixture
• AMlopres-d4
• (R,S)-AMlodipine-d4
• Amlodipine, racemic mixture
• (+)-AMlodipine-d4
• UK-48340-d4
• 2-[(2-AMinoethoxy)Methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-dihydropyridine-d4
• (4R)-2-[[2-AMino(ethoxy-d4)]ethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
• (R)-AMlodipine-d4

Amlodipine-d4 Maleate

CAS: 1185246-14-3, 1185246-15-4

Formula: C₂₀H₂₁D₄ClN₂O₅·C₄H₄O₄

Color and Shape: Off-White Solid

Molecular weight: 412.90 116.07

Ref: 4Z-A-082

Amlodipine Impurity 22 (Z-Isomer)

CAS: 1185246-14-3, 1185246-15-4

Formula: C₂₃H₂₀ClNO₆

Color and Shape: White To Off-White Solid

Molecular weight: 441.86

Ref: 4Z-A-0825

Amlodipine-d4

Controlled Product

CAS: 1185246-14-3

Applications Labelled Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.
References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995),

Formula: C₂₀H₂₁D₄ClN₂O₅

Color and Shape: Light Yellow

Molecular weight: 412.9

Ref: TR-A633497