CAS 118609-38-4

Fmoc-D-Thr-OH

Description:

Fmoc-D-Thr-OH, or 9-fluorenylmethoxycarbonyl-D-threonine, is a protected amino acid commonly used in peptide synthesis. It features a fluorenylmethoxycarbonyl (Fmoc) group, which serves as a protective group for the amino functionality, allowing for selective reactions at the carboxyl group. This compound is characterized by its stability under basic conditions, making it suitable for solid-phase peptide synthesis. The D-threonine component contributes to its chirality, as it is the D-enantiomer of threonine, an essential amino acid involved in protein synthesis. Fmoc-D-Thr-OH is typically soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane, but less soluble in water. Its molecular structure includes a hydroxyl group, which can participate in hydrogen bonding, influencing its reactivity and interactions in biochemical contexts. The use of Fmoc-D-Thr-OH in research and pharmaceutical applications highlights its importance in the development of peptide-based therapeutics and bioconjugates.

Formula: C₁₉H₁₉NO₅

InChI: InChI=1/C19H19NO5/c1-11(21)17(18(22)23)20-19(24)25-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16-17,21H,10H2,1H3,(H,20,24)(H,22,23)/t11?,17-/m1/s1

SMILES: CC([C@H](C(=O)O)N=C(O)OCC1c2ccccc2c2ccccc12)O

Synonyms:

• N-Alpha-(9-Fluorenylmethoxycarbonyl)-D-Threonine
• N-Alpha-Fmoc-D-Threonine
• N-Alpha-Fmoc-D-Threonine / (2R,3S)
• Fmoc-D-Thr
• Fmoc-D-Threonine
• Fmoc-D-Thr Br
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-threonine
• N-Fmoc-D-Threonine
• FMOC-D-THREONINE extrapure
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-allothreonine
• (2R,3S)-2-({[1-(9H-fluoren-9-yl)ethoxy]carbonyl}amino)-3-hydroxybutanoic acid
• D-Threonine, N-[[1-(9H-fluoren-9-yl)ethoxy]carbonyl]-
• FMOC-D-THR-OH
• N-[[1-(9H-Fluoren-9-yl)ethoxy]carbonyl]-D-threonine
• Fmoc-D-threonine≥ 97% (HPLC)