CAS 1186486-62-3

Evacetrapib

Description:

Evacetrapib is a small molecule that functions as a selective inhibitor of the enzyme cholesteryl ester transfer protein (CETP). This compound is primarily investigated for its potential in treating dyslipidemia and cardiovascular diseases by modulating lipid profiles, particularly by increasing high-density lipoprotein (HDL) cholesterol levels while reducing low-density lipoprotein (LDL) cholesterol levels. Evacetrapib is characterized by its specific chemical structure, which includes various functional groups that contribute to its biological activity and selectivity. The compound has undergone various clinical trials to assess its efficacy and safety, particularly in relation to cardiovascular outcomes. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic potential and dosing regimens. Overall, Evacetrapib represents a significant area of research in lipid management and cardiovascular health, although its clinical development has faced challenges that have influenced its market viability.

Formula: C₃₁H₃₆F₆N₆O₂

InChI: InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20-,22-,26-/m0/s1

InChI key: InChIKey=IHIUGIVXARLYHP-YBXDKENTSA-N

SMILES: N(CC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)([C@@H]2C=3C(N(C[C@@H]4CC[C@@H](C(O)=O)CC4)CCC2)=C(C)C=C(C)C3)C=5N=NN(C)N5

Synonyms:

• Cyclohexanecarboxylic acid, 4-[[(5S)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-, trans-
• Ly-2484595
• Ly2484595
• trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid
• Evacetrapib

Evacetrapib (LY2484595)

CAS: 1186486-62-3

Formula: C₃₂H₃₇F₆N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 637.6589

Ref: IN-DA008TG5

Evacetrapib

CAS: 1186486-62-3

Evacetrapib

Purity: ≥98%

Molecular weight: 638.65g/mol

Ref: 54-BUP05924

Evacetrapib

CAS: 1186486-62-3

Evacetrapib (LY2484595) inhibits CETP strongly (IC50=5.5 nM), raises HDL cholesterol, no rise in aldosterone/blood pressure. Phase 3.

Formula: C₃₁H₃₆F₆N₆O₂

Purity: 98.53%

Color and Shape: Solid

Molecular weight: 638.65

Ref: TM-T6262