CAS 1187594-09-7: Baricitinib
Description:Baricitinib is a small molecule drug primarily used for the treatment of moderate to severe rheumatoid arthritis. It functions as a selective inhibitor of Janus kinase (JAK) enzymes, specifically JAK1 and JAK2, which play a crucial role in the signaling pathways of various cytokines involved in inflammatory processes. The chemical formula of Baricitinib is C16H17N3O2, and it has a molecular weight of approximately 285.33 g/mol. The substance appears as a white to off-white crystalline powder and is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water. Baricitinib is administered orally and has been shown to reduce the signs and symptoms of rheumatoid arthritis by modulating the immune response. Its pharmacokinetics indicate a relatively long half-life, allowing for once-daily dosing. As with any medication, potential side effects include increased risk of infections, liver enzyme elevations, and changes in blood cell counts, necessitating monitoring during treatment.
Formula:C16H17N7O2S
InChI:InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChI key:InChIKey=XUZMWHLSFXCVMG-UHFFFAOYSA-N
SMILES:N#CCC1(N2N=CC(=C2)C=3N=CN=C4NC=CC43)CN(C1)S(=O)(=O)CC
- Synonyms:
- 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
- 2-(3-(4-(3H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
- 2-(3-(4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
- 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-
- Incb 028050
- Incb 28050
- Incb028050
- Ly 3009104
- Ly3009104
- Olumiant
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