CAS 1187595-84-1

Baricitinib phosphate salt

Description:

Baricitinib phosphate salt is a pharmaceutical compound primarily used as a treatment for rheumatoid arthritis and has gained attention for its potential in treating COVID-19. It is a selective inhibitor of Janus kinase (JAK) enzymes, which play a crucial role in the signaling pathways of various cytokines involved in inflammatory processes. The compound is characterized by its ability to modulate immune responses, thereby reducing inflammation and joint damage in autoimmune conditions. Baricitinib phosphate salt is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good absorption and distribution in the body. Its chemical structure includes a phosphate group, which enhances its solubility and bioavailability. Safety and efficacy profiles have been established through clinical trials, although potential side effects may include increased risk of infections and changes in blood cell counts. Overall, Baricitinib phosphate salt represents a significant advancement in targeted therapies for inflammatory diseases.

Synonyms:

• [1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl]acetonitrile phosphate
• 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile phosphate

Baricitinib phosphate salt

CAS: 1187595-84-1

Formula: C₁₆H₂₀N₇O₆PS

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.4121

Ref: IN-DA008TDT

Baricitinib phosphate

CAS: 1187595-84-1

Baricitinib phosphate

Purity: ≥98%

Molecular weight: 469.41g/mol

Ref: 54-BUP10585

2-(3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-1-(Ethylsulfonyl)Azetidin-3-Yl)Acetonitrile Phosphate

CAS: 1187595-84-1

2-(3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-1-(Ethylsulfonyl)Azetidin-3-Yl)Acetonitrile Phosphate

Purity: 98%

Molecular weight: 469.41g/mol

Ref: 54-OR1026276

Baricitinib phosphate

CAS: 1187595-84-1

Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.

Formula: C₁₆H₂₀N₇O₆PS

Purity: 99.4% - 99.82%

Color and Shape: Solid

Molecular weight: 469.41

Ref: TM-T2360

Baricitinib phosphate

Controlled Product

CAS: 1187595-84-1

Baricitinib phosphate is a selective Janus kinase (JAK) inhibitor, which is a synthetic product developed through targeted molecular design. Its mode of action involves the inhibition of JAKs, which are intracellular enzymes that transmit cytokine-mediated signals via the JAK-STAT pathway. By blocking these signals, baricitinib phosphate effectively reduces inflammatory responses.

Formula: C₁₆H₂₀N₇O₆PS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 469.41 g/mol

Ref: 3D-MXB59584