CAS 1188-21-2

N-Acetyl-L-leucine

Description:

N-Acetyl-L-leucine is an acetylated derivative of the amino acid leucine, characterized by its structural formula that includes an acetyl group attached to the nitrogen of the leucine side chain. This compound is a white to off-white crystalline powder, soluble in water and organic solvents, which makes it versatile for various applications. N-Acetyl-L-leucine is known for its role in biochemical processes and is often studied for its potential therapeutic effects, particularly in the context of neurological conditions and metabolic disorders. It may also serve as a building block in peptide synthesis and as a chiral auxiliary in organic synthesis. The compound exhibits stability under standard conditions, though it should be stored in a cool, dry place to maintain its integrity. As with many amino acid derivatives, it is important to handle N-Acetyl-L-leucine with care, following appropriate safety guidelines to avoid any potential hazards associated with chemical exposure.

Formula: C₈H₁₅NO₃

InChI: InChI=1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

InChI key: InChIKey=WXNXCEHXYPACJF-ZETCQYMHSA-N

SMILES: [C@@H](CC(C)C)(NC(C)=O)C(O)=O

Synonyms:

• (-)-N-Acetyl-<span class="text-smallcaps">L</span>-leucine
• (2S)-2-(acetylamino)-4-methylpentanoate
• (2S)-2-Acetamido-4-methylpentanoic acid
• (S)-2-Acetamido-4-methylpentanoic acid
• <span class="text-smallcaps">L</span>-Leucine, N-acetyl-
• Ac-Leu-OH
• Acetyl-<span class="text-smallcaps">L</span>-leucine
• Acetylleucine
• Leucine, N-acetyl-, <span class="text-smallcaps">L</span>-
• N-acetylleucine
• NSC 206316
• Leucine, N-acetyl-, L-
• Acetyl-L-leucine
• N-Acetyl-L-leucine

N-Acetyl-L-leucine

CAS: 1188-21-2

Formula: C₈H₁₅NO₃

Purity: >99.0%(T)

Color and Shape: White to Almost white powder to lump

Molecular weight: 173.21

Ref: 3B-A0098

N-Acetyl-L-leucine, 99%

CAS: 1188-21-2

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₈H₁₅NO₃

Purity: 99%

Color and Shape: White, Crystals or powder or crystalline powder

Molecular weight: 173.21

Ref: 02-L13926

N-Acetyl-L-leucine

CAS: 1188-21-2

Formula: C₈H₁₅NO₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 173.2096

Ref: IN-DA0035C1

N-Acetyl-L-leucine

CAS: 1188-21-2

Formula: C₈H₁₅NO₃

Molecular weight: 173.21

Ref: 7W-GM6611

N-Acetyl-L-leucine

CAS: 1188-21-2

N-Acetyl-L-leucine

Purity: ≥98%

Molecular weight: 173.21g/mol

Ref: 54-BUP18435

N-Acetyl-L-leucine

CAS: 1188-21-2

N-Acetyl-L-leucine

Formula: C₈H₁₅NO₃

Color and Shape: white crystalline powder

Molecular weight: 173.21g/mol

Ref: 54-BIA1765

N-Acetyl-L-leucine

CAS: 1188-21-2

N-Acetylleucine, a water-soluble, weakly acidic derivative of leucine, is found in biofluids like feces and saliva.

Formula: C₈H₁₅NO₃

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 173.21

Ref: TM-T4798

N-Acetyl-L-(-)-leucine

CAS: 1188-21-2

Applications N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.
References Zheng, C. et al.: Bioorg. Med. Chem. Lett., 22, 39 (2012); Miki, K. et al.: Bull. Chem. Soc. Jap., 85, 1277 (2012);

Formula: C₈H₁₅NO₃

Color and Shape: Neat

Molecular weight: 173.21

Ref: TR-A185035

N-Acetyl-L-leucine

CAS: 1188-21-2

N-Acetyl-L-leucine is a natural amino acid that has been shown to have therapeutic potential in the treatment of neurodegenerative diseases. N-acetyl-L-leucine binds to DNA duplexes and inhibits the formation of protein aggregates, which are associated with neurodegenerative disorders. N-acetyl-L-leucine also has a high affinity for neuronal receptors, which may be due to its basic nature. In addition, this compound is able to inhibit oxidative stress induced by glutamate and nitric oxide, as well as mitochondrial membrane potential loss. It also protects against neuronal death induced by amide or cytosolic Ca2+.

Formula: C₈H₁₅NO₃

Color and Shape: White Powder

Molecular weight: 173.21 g/mol

Ref: 3D-FA10862

Ac-Leu-OH

CAS: 1188-21-2

M03063 - Ac-Leu-OH

Formula: C₈H₁₅NO₃

Purity: 95%

Color and Shape: Solid, Crystalline

Molecular weight: 173.212

Ref: 10-M03063

N-Acetyl-L-Leucine extrapure, 99%

CAS: 1188-21-2

Formula: C₈H₁₅NO₃

Purity: min. 99%

Color and Shape: White, Crystalline powder

Molecular weight: 173.21

Ref: SR-76097

N-Acetyl-L-Leucine (Acetyl-L-leucine)

CAS: 1188-21-2

Acyclic amides (including acyclic carbamates) and their derivatives and salts thereof, nesoi

Formula: C₈H₁₅NO₃

Color and Shape: White Powder

Molecular weight: 173.10519

Ref: 45-1010081