CAS 1188265-58-8

ZONISAMIDE-13C2-15N

Description:

Zonisamide-13C2-15N is a stable isotope-labeled derivative of zonisamide, a medication primarily used as an anticonvulsant for the treatment of epilepsy and as an adjunct therapy for Parkinson's disease. The incorporation of carbon-13 (13C) and nitrogen-15 (15N) isotopes allows for enhanced tracking and analysis in metabolic studies and pharmacokinetic research. This compound retains the core structure and pharmacological properties of zonisamide, which includes its ability to inhibit sodium and calcium channels, as well as its action on neurotransmitter systems. Zonisamide is known for its low potential for drug interactions and side effects, making it a favorable option in polytherapy for epilepsy. The isotopic labeling in Zonisamide-13C2-15N aids in understanding its absorption, distribution, metabolism, and excretion (ADME) in biological systems, providing valuable insights into its pharmacological behavior. As with any chemical substance, safety and handling precautions should be observed, particularly in research settings.

Formula: C₈H₈N₂O₃S

InChI: InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)/i5+1,7+1,9+1

InChI key: InChIKey=UBQNRHZMVUUOMG-VDWPWFDKSA-N

SMILES: [13CH2](S([15NH2])(=O)=O)[13C]=1C=2C(ON1)=CC=CC2

Synonyms:

• ZONISAMIDE-13C2-15N

Zonisamide-13C2-15N (Sulfonamide)

CAS: 1188265-58-8

Formula: C₆₁₃C₂H₈N₁₅NO₃S

Color and Shape: White To Off-White Solid

Molecular weight: 215.20

Ref: 4Z-Z-031

Zonisamide-13C2-15N

CAS: 1188265-58-8

Applications Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.
References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980); Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987); Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993); Sorkin, E.M., et al.: Drugs, 45, 760 (1993)

Formula: C₆₁₃C₂H₈N₁₅NO₃S

Color and Shape: Off-White To Light Yellow

Molecular weight: 215.2

Ref: TR-Z700003

Zonisamide-13C2-15N

CAS: 1188265-58-8

Zonisamide-13C2-15N is a labeled form of zonisamide, which belongs to the group of ion channel blockers. It is used as a research tool in cell biology and pharmacology. This compound has been shown to be an inhibitor of protein interactions with peptides and antibodies. Zonisamide-13C2-15N has been used to study the activation mechanism for beta adrenergic receptors and serotonin 5HT1A receptors.

Formula: C₆₁₃C₂H₈N₁₅NO₃S

Purity: Min. 95%

Molecular weight: 215.2 g/mol

Ref: 3D-NXB26558