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CAS 118905-01-4

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carbocyclic 2'-deoxyguanosine 5'-triphosphate

Description:
Carbocyclic 2'-deoxyguanosine 5'-triphosphate (c-dGTP) is a modified nucleotide that serves as a building block for nucleic acids, particularly in the context of DNA synthesis. This compound features a carbocyclic structure, which replaces the natural ribose sugar with a cyclic carbon framework, enhancing its stability and resistance to enzymatic degradation. The 5'-triphosphate group is crucial for its role in energy transfer and as a substrate for DNA polymerases during DNA replication and repair processes. c-dGTP is characterized by its ability to participate in base pairing with complementary nucleotides, maintaining the integrity of the genetic code. Its unique structure allows for potential applications in molecular biology and therapeutic development, particularly in the design of antiviral agents or in gene editing technologies. The CAS number 118905-01-4 uniquely identifies this compound, facilitating its recognition in scientific literature and databases. Overall, c-dGTP represents an important tool in biochemistry and molecular genetics, contributing to advancements in research and biotechnology.
Formula:C11H16N5O6P
InChI:InChI=1/C11H16N5O6P/c12-11-14-9-8(10(18)15-11)13-4-16(9)6-1-5(7(17)2-6)3-22-23(19,20)21/h4-7,17H,1-3H2,(H2,19,20,21)(H3,12,14,15,18)/t5-,6-,7+/m1/s1
Synonyms:
  • Cdg-TP
  • 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxy-4-((phosphonooxy)methyl)cyclopentyl)-, (1R-(1alpha,3beta,4alpha))-
  • [(1R,2S,4R)-4-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-2-hydroxycyclopentyl]methyl dihydrogen phosphate
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  • Carbocyclic 2'-deoxyguanosine 5'-triphosphate
    Biosynth
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    Carbocyclic 2'-deoxyguanosine 5'-triphosphate

    CAS:
    <p>Carbocyclic 2'-deoxyguanosine 5'-triphosphate is a nucleotide analog that inhibits the synthesis of DNA by binding to the template strand. This drug inhibits the replication of herpes simplex virus and is being investigated as a cancer treatment. Carbocyclic 2'-deoxyguanosine 5'-triphosphate binds to the dna template strand and prevents viral DNA from being replicated. It also has inhibitory effects on telomerase, the enzyme that prevents chromosome shortening and cell death during replication.</p>
    Formula:C11H16N5O6P
    Purity:Min. 95%
    Molecular weight:345.25 g/mol

    Ref: 3D-NC29202

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