CAS 118909-22-1

Velnacrine maleate

Description:

Velnacrine maleate is a chemical compound that belongs to the class of drugs known as cholinesterase inhibitors, primarily investigated for its potential use in treating cognitive disorders, including Alzheimer's disease. It is characterized by its ability to enhance cholinergic neurotransmission by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. This action may lead to improved cognitive function and memory. The maleate salt form indicates that it is combined with maleic acid, which can influence its solubility and stability. Velnacrine maleate is typically administered in a pharmaceutical context, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining its efficacy and safety profile. As with many compounds in this category, potential side effects may include gastrointestinal disturbances and central nervous system effects. Research continues to explore its therapeutic potential and optimize its use in clinical settings.

Formula: C₁₃H₁₄N₂O·C₄H₄O₄

InChI: InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=NEEKVKZFYBQFGT-BTJKTKAUSA-N

SMILES: NC1=C2C(=NC=3C1=CC=CC3)CCCC2O.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (+-)-9-Amino-1,2,3,4-tetrahydro-1-acridinol maleate (1:1) (salt)
• 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (+-)-, (Z)-2-butenedioate (1:1) (salt)
• 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (2Z)-2-butenedioate (1:1)
• 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (2Z)-2-butenedioate (1:1) (salt)
• Hp 029
• Mentane
• P 83-6029A
• Unii-Yy1Jw04Jcb
• Velnacrine hydrogen maleate
• Velnacrine maleate

9-Amino-1,2,3,4-tetrahydroacridin-1-ol maleate

CAS: 118909-22-1

Formula: C₁₇H₁₈N₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 330.3352

Ref: IN-DA003NJY

Hydroxytacrine maleate

CAS: 118909-22-1

Hydroxytacrine maleate

Purity: ≥98%

Molecular weight: 330.34g/mol

Ref: 54-BUP13978

9-Amino-1-hydroxy-1,2,3,4-tetrahydroacridine maleate

CAS: 118909-22-1

9-Amino-1-hydroxy-1,2,3,4-tetrahydroacridine maleate

Purity: ≥95%

Color and Shape: White Solid

Molecular weight: 330.34g/mol

Ref: 54-OR2990T

Hydroxytacrine maleate

CAS: 118909-22-1

Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase inhibitor used in the study of Alzheimer's type dementia (SDAT).

Formula: C₁₇H₁₈N₂O₅

Purity: 98.84%

Color and Shape: Solid

Molecular weight: 330.34

Ref: TM-T21556

(±)-Velnacrine-1,2,2-d3 Maleat(1-Hydroxytacrine Maleate)

CAS: 118909-22-1

Purity: 99 atom % D (also 12%-4,4-d2)

Color and Shape: White Solid

Molecular weight: 333.36

Ref: 3U-D7200

9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate

Controlled Product

CAS: 118909-22-1

Applications A potential Alzheimer's Disease therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to THA except that it is far less toxic and without measurable liver toxicity in humans.
References Alon, R., et al.: J. Cell Biol., 128, 1243 (1995), Min, W., et al.: J .Immunol., 159, 3508 (1997), Lum, A., et al.: J. Biol. Chem., 277, 20660 (2002), Carvalho, F., et al.: J. Appl. Toxicol., 24, 419 (2004),

Formula: C₁₃H₁₄N₂O·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 330.34

Ref: TR-A629900

Hydroxytacrine maleate salt

CAS: 118909-22-1

Cholinesterase inhibitor. Potential Alzheimer's disease therapeutic This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Formula: C₁₇H₁₈N₂O₅

Molecular weight: 330.34

Ref: 02-J60680