Nilutamide-d6 is a deuterated form of nilutamide, which is a non-steroidal anti-androgen used primarily in the treatment of prostate cancer. The deuteration, indicated by the "d6" in its name, means that six hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving metabolic pathways and drug interactions. Nilutamide itself functions by blocking androgen receptors, thereby inhibiting the effects of androgens like testosterone on prostate cancer cells. The chemical structure of nilutamide-d6 retains the core characteristics of nilutamide, including its ability to bind to androgen receptors, but the presence of deuterium can provide insights into its behavior in biological systems. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by appropriate regulatory standards.

Nilutamide-d
6
is intended for use as an internal standard for the quantification of nilutamide by GC- or LC-MS. Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor. It reverses testosterone-induced increases in cell proliferation with an IC
50
value of 412 nM in mouse mammary carcinoma cells
in vitro
. It has antiandrogenic activity in both intact and castrated rats, inhibiting testosterone propionate-induced prostate growth when administered at a dose of 2.5 mg/kg. Formulations containing nilutamide have been used in combination with surgical castration in the treatment of metastatic prostate cancer.

Nilutamide-d6

1189477-66-4: Nilutamide-d6 is a deuterated form of nilutamide, which is a non-steroidal anti-androgen used primarily in the treatment of prostate cancer. The deuteration, indicated by the "d6" in its name, means that six hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in studies involving metabolic pathways and drug interactions. Nilutamide itself functions by blocking androgen receptors, thereby inhibiting the effects of androgens like testosterone on prostate cancer cells. The chemical structure of nilutamide-d6 retains the core characteristics of nilutamide, including its ability to bind to androgen receptors, but the presence of deuterium can provide insights into its behavior in biological systems. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by appropriate regulatory standards.

CAS 1189477-66-4

Nilutamide-d6

Nilutamide-d6

Ref: 4Z-N-401

Nilutamide-d6

Ref: TR-N467502