Clomipramine-d6 N-Oxide is a deuterated derivative of clomipramine, a tricyclic antidepressant primarily used to treat obsessive-compulsive disorder and depression. The "d6" designation indicates that six hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in various research applications, including pharmacokinetics and metabolic studies. The N-oxide form suggests that the nitrogen atom in the molecule has been oxidized, which can influence the compound's pharmacological properties and metabolic pathways. Clomipramine-d6 N-Oxide retains the core structure of clomipramine, which includes a dibenzazepine framework, contributing to its interaction with neurotransmitter systems, particularly serotonin and norepinephrine. This compound is typically used in scientific research rather than clinical settings, allowing for the study of clomipramine's behavior in biological systems without interference from naturally occurring isotopes. As with any chemical substance, safety and handling precautions should be observed, and its use should comply with relevant regulations.

Clomipramine-d6 N-Oxide

1189479-06-8: Clomipramine-d6 N-Oxide is a deuterated derivative of clomipramine, a tricyclic antidepressant primarily used to treat obsessive-compulsive disorder and depression. The "d6" designation indicates that six hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which can be useful in various research applications, including pharmacokinetics and metabolic studies. The N-oxide form suggests that the nitrogen atom in the molecule has been oxidized, which can influence the compound's pharmacological properties and metabolic pathways. Clomipramine-d6 N-Oxide retains the core structure of clomipramine, which includes a dibenzazepine framework, contributing to its interaction with neurotransmitter systems, particularly serotonin and norepinephrine. This compound is typically used in scientific research rather than clinical settings, allowing for the study of clomipramine's behavior in biological systems without interference from naturally occurring isotopes. As with any chemical substance, safety and handling precautions should be observed, and its use should comply with relevant regulations.

<p>Applications A labelled metabolite of Clomipramine.<br>References Gottschalk, L., et al.: J. Pharm. Sci., 67, 155 (1978), de Jongh, G., et al.: Drug Metab. Dispos., 9, 48 (1981), Delbressine, L., et al.: Xenobiotica, 22, 227 (1992), Jaworski, T., et al.: J. Pharm. Sci., 82, 330 (1993), Kelder, J., et al.: J. Pharm. Pharmacol., 49, 403 (1997),<br></p>

CAS 1189479-06-8

Clomipramine-d6 N-Oxide

Clomipramine-d6 N-Oxide

Ref: TR-C587062