CAS 1189481-51-3

Elacridar-d4

Description:

Elacridar-d4 is a deuterated form of Elacridar, a compound primarily known for its role as a potent inhibitor of P-glycoprotein (P-gp), which is involved in drug transport and multidrug resistance in cancer therapy. The deuteration (indicated by the "d4" suffix) refers to the substitution of hydrogen atoms with deuterium, a stable isotope of hydrogen, which can enhance the compound's pharmacokinetic properties and stability during metabolic processes. Elacridar-d4 retains the structural characteristics of its parent compound, featuring a complex molecular framework that allows it to effectively interact with P-gp. This modification can also aid in tracing and studying the compound's behavior in biological systems through techniques such as mass spectrometry. Overall, Elacridar-d4 is significant in research focused on overcoming drug resistance in cancer treatments and improving the bioavailability of therapeutic agents.

Formula: C₃₄H₃₃N₃O₅

InChI: InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)/i14D2,16D2

InChI key: InChIKey=OSFCMRGOZNQUSW-RCYYZLFTSA-N

SMILES: C(NC1=CC=C(C(C(N2CC=3C(CC2)=CC(OC)=C(OC)C3)([2H])[2H])([2H])[2H])C=C1)(=O)C4=C5C(C(=O)C=6C(N5)=C(OC)C=CC6)=CC=C4

Synonyms:

• GF 120918-d4
• N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl-d4]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
• 5-Methoxy-9-oxo-N-[4-[1,1,2,2-tetradeuterio-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-10H-acridine-4-carboxamide
• GW 0918-d4
• Elacridar-d4
• GG 918-d4
• 5-methoxy-9-oxo-N-[4-[1,1,2,2-tetradeuterio-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-10H-acridine-4-carboxamide

Elacridar-d4 (Major)

Controlled Product

CAS: 1189481-51-3

Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.
References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007).

Formula: C₃₄H₂₉D₄N₃O₅

Color and Shape: Light Yellow To Yellow

Molecular weight: 567.67

Ref: TR-E489002

Elacridar-d4

CAS: 1189481-51-3

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Formula: C₃₄H₃₃N₃O₅

Purity: Min. 95%

Molecular weight: 567.7 g/mol

Ref: 3D-PXB48151